{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:39:51Z","timestamp":1776134391367,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic corticosteroids have long been the mainstay of treatment for pemphigus patients. However, the necessity of their high\u2010dose and long\u2010term administration has brought about a number of complications, sometimes causing significant morbidities. Maintaining a balance between therapeutic and undesirable effects of medications is not always easily achievable. Therefore, additional treatment modalities are frequently needed to control side\u2010effects. Kaposi's sarcoma (KS) is a rare, potentially life\u2010threatening complication in this setting. Due to the rarity of data on pemphigus\u2010associated <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content> treatment, the best therapeutic approach is still undecided. Here, we report two cases of pemphigus patients who had developed extensive KS as a result of severe immunosuppressive therapy and were successfully treated with paclitaxel. In addition, we performed a review of literature to assess the results of the previously employed treatment modalities in this setting.<\/jats:p>","DOI":"10.1111\/jdv.12348","type":"journal-article","created":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T07:46:51Z","timestamp":1387266411000},"page":"987-994","source":"Crossref","is-referenced-by-count":9,"title":["Pemphigus vulgaris\u2010associated Kaposi's sarcoma: response to paclitaxel and review of the literature"],"prefix":"10.1111","volume":"28","author":[{"given":"K.","family":"Balighi","sequence":"first","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Aghazadeh","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Aryanian","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Azizpour","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Rahbar","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Goodarzi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Chams\u2010Davatchi","sequence":"additional","affiliation":[{"name":"Autoimmune Bullous Diseases Research Centre Razi hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01830024"},{"key":"e_1_2_5_3_1","first-page":"305","article-title":"Kaposi's sarcoma and Pneumocystis pneumonia among homosexual men \u2014 New York City and California","volume":"30","author":"Friedman\u2010Kien AE","year":"1981","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421407"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90001-L"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7997879"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7725108"},{"key":"e_1_2_5_8_1","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1001\/archinte.1996.00440020112014","article-title":"Kaposi's sarcoma associated herpesvirus and Kaposi's sarcoma in Africa","volume":"156","author":"Chang Y","year":"1996","journal-title":"Arch Int Med"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90780-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0795-707"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<68::AID-IJC10>3.0.CO;2-6"},{"key":"e_1_2_5_12_1","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1128\/JVI.73.7.6136-6140.1999","article-title":"Identification of human herpesvirus 8\u2010specific cytotoxic T\u2010cell responses","volume":"73","author":"Osman M","year":"1999","journal-title":"J Virol"},{"key":"e_1_2_5_13_1","first-page":"956","article-title":"gamma\u2010Interferon produced by CD8+ T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with HIV\u20101 Tat protein: an immune response to HHV\u20108 infection?","volume":"91","author":"Fiorelli V","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_14_1","first-page":"4044","article-title":"Reactivation and persistence of human herpesvirus\u20108 infection in B cells and monocytes by Th\u20101 cytokines increased in Kaposi's sarcoma","volume":"93","author":"Monini P","year":"1999","journal-title":"Blood"},{"key":"e_1_2_5_15_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1182\/blood.V91.3.968","article-title":"gamma\u2010Interferon production in peripheral blood mononuclear cells and tumour infiltrating lymphocytes from Kaposi's sarcoma patients: correlation with the presence of human herpesvirus\u20108 in PBMC and lesional macrophages","volume":"91","author":"Sirianni MC","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.882"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12286343"},{"key":"e_1_2_5_18_1","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1001\/archderm.1997.03890460069008","article-title":"Human herpesvirus 8 DNA sequences in blistering skin from patients with pemphigus","volume":"133","author":"Memar OM","year":"1997","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00384.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00932-2.x"},{"key":"e_1_2_5_21_1","first-page":"456","article-title":"Absence of human herpesvirus 8 in pemphigus and bullous pemphigoid","volume":"2","author":"Galan A","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_5_22_1","first-page":"1360","article-title":"Kaposi's sarcoma and KSHV","volume":"346","author":"Franceschi S","year":"1995","journal-title":"Lancet"},{"key":"e_1_2_5_23_1","first-page":"16","article-title":"Kaposi's sarcoma in renal transplant recipients: experience at Johannesburg Hospital, 1966\u20131989","volume":"84","author":"Margolius L","year":"1994","journal-title":"S Afr Med J"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168700"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.1.509"},{"key":"e_1_2_5_26_1","first-page":"1843","article-title":"The microtubule\u2010affecting drug paclitaxel has antiangiogenic activity","volume":"2","author":"Belotti D","year":"1996","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.1112"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10634"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg461"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.10.3478"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-6143.2002.20911.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21791"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.5.654"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2006.00815.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.10.076"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042831"},{"key":"e_1_2_5_37_1","first-page":"269","article-title":"Kaposi's sarcoma in a patient with pemphigus","volume":"2","author":"Rosenmann E","year":"1966","journal-title":"Isr J Med Sci"},{"key":"e_1_2_5_38_1","first-page":"89","article-title":"Kaposi's sarcoma","volume":"25","author":"Pisanty S","year":"1970","journal-title":"J Oral Med"},{"key":"e_1_2_5_39_1","unstructured":"SportesB.Contribution a l'etude des maladies de Kaposi induites par immunosuppression[thesis].St. Antoine Hospital CHU Neber University Paris France 1978:156."},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1978.tb01477.x"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250141"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250215"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70074-1"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1989.tb03132.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930901)72:5<1779::AID-CNCR2820720543>3.0.CO;2-M"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01348.x"},{"key":"e_1_2_5_47_1","first-page":"29","article-title":"Iatrogenically induced sarkoma Kaposi in a patient with pemphigus vulgaris","volume":"12","author":"Racheva S","year":"2006","journal-title":"J IMAB \u2010 Annual Proc (Scientific Papers)"},{"key":"e_1_2_5_48_1","first-page":"363","article-title":"Kaposi's sarcoma after treatment for bullous pemphigoid or pemphigus","volume":"17","author":"Desinioti K","year":"2006","journal-title":"Greek Review Dermatologias Afrodisiologias"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03035.x"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8.709"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12348","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:13:31Z","timestamp":1695554011000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,17]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jdv.12348"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12348","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,17]]}}}