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In reality, more than 50 different drugs have been associated with the appearance of bullous pemphigoid and as new therapies emerge, this number is very likely to increase. A number of pathogenetic mechanisms have been proposed in the past. It is true that a delicate immunological balance is disturbed in all patients with the disease. The variable effects that may be exhibited by the use of biological drugs could shed some light in this complex immunological behaviour. At the same time, drug\u2010induced bullous pemphigoid is difficult to differentially diagnose from its idiopathic counterpart, as the clinical picture and histopathological findings in both conditions may only have subtle differences. Patients who present with bullous pemphigoid and receive multiple regimens should always be suspected of suffering from the drug\u2010induced variant of the condition. This possibility must be considered, as after the withdrawal of the suspect medication most patients respond rapidly to treatment and do not experience relapses.<\/jats:p>","DOI":"10.1111\/jdv.12366","type":"journal-article","created":{"date-parts":[[2014,1,10]],"date-time":"2014-01-10T13:39:25Z","timestamp":1389361165000},"page":"1133-1140","source":"Crossref","is-referenced-by-count":213,"title":["Drug\u2010induced pemphigoid: a review of the literature"],"prefix":"10.1111","volume":"28","author":[{"given":"P.G.","family":"Stavropoulos","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u201cAndreas Sygros\u201d Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Soura","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u201cAndreas Sygros\u201d Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u201cAndreas Sygros\u201d Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-007-0030-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1201\/b14278-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70262-R"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1001\/archderm.1984.01650450078023","article-title":"Bullous pemphigoid\u2010like lesions induced by phenacetin. 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