{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:03Z","timestamp":1787015523439,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Janssen-Cilag Pharmaceuticals"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis can be found at several different localizations which may be of various impact on patients' quality of life (QoL). One of the easy visible, and difficult to conceal localizations are the nails.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To achieve more insight into the QoL of psoriatic patients with nail psoriasis, and to characterize the patients with nail involvement which are more prone to the impact of the nail alterations caused by psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A self\u2010administered questionnaire was distributed to all members (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a05400) of the Dutch Psoriasis Association. The Dermatology Life Quality Index (\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      ) and the Nail Psoriasis Quality of life 10 (\n                      <jats:styled-content style=\"fixed-case\">NPQ<\/jats:styled-content>\n                      10) score were included as QoL measures. Severity of cutaneous lesions was determined using the self\u2010administered psoriasis area and severity index (\n                      <jats:styled-content style=\"fixed-case\">SAPASI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with nail psoriasis scored significantly higher mean scores on the\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      (4.9 vs. 3.7,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0&lt;0.001) and showed more severe psoriasis (\n                      <jats:styled-content style=\"fixed-case\">SAPASI<\/jats:styled-content>\n                      , 6.6 vs. 5.3,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0&lt;0.001). Patients with coexistence of nail bed and nail matrix features showed higher\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      scores compared with patients with involvement of one of the two localizations exclusively (5.3 vs. 4.2 vs. 4.3,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.003). Patients with only nail bed alterations scored significant higher\n                      <jats:styled-content style=\"fixed-case\">NPQ<\/jats:styled-content>\n                      10 scores when compared with patients with only nail matrix features. Patients with psoriatic arthritis (PsA) and nail psoriasis experiences more impairments compared with nail psoriasis patients without PsA (\n                      <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>\n                      5.5 vs. 4.3,\n                      <jats:styled-content style=\"fixed-case\">NPQ<\/jats:styled-content>\n                      10 13.3 vs. 7.0). Females scored higher mean scores on all QoL scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Greater attention should be paid to the possible impact nail abnormalities have on patients with nail psoriasis, which can be identified by nail psoriasis specific questionnaires such as the\n                      <jats:styled-content style=\"fixed-case\">NPQ<\/jats:styled-content>\n                      10. As improving the severity of disease may have a positive influence on QoL, the outcome of QoL measurements should be taken into account when deciding on treatment strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12368","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T02:51:29Z","timestamp":1389754289000},"page":"1690-1695","source":"Crossref","is-referenced-by-count":58,"title":["Nail Psoriasis, the unknown burden of disease"],"prefix":"10.1111","volume":"28","author":[{"given":"K.M.G.","family":"Klaassen","sequence":"first","affiliation":[{"name":"Department of Dermatology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.M.","family":"van de Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Dermatology Radboud University Nijmegen Medical Centre Nijmegen The 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