{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T06:41:28Z","timestamp":1740120088859,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010740","name":"Asahi Kasei Pharma Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010740","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Maruho Co., Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Herpes zoster (HZ), a reactivation of varicella zoster virus manifested by skin blisters and neuralgia, can lead to postherpetic neuralgia in 10\u201320% of affected subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study, a cohort of 764 patients with HZ was treated with 1500\u00a0mg\/day of famciclovir for 7\u00a0days, and zoster\u2010associated pain (ZAP) was monitored monthly thereafter for up to 12\u00a0months until pain resolution was achieved. Patients were questioned monthly by telephone, and pain was recorded using a numerical rating scale (NRS, 0\u201310).<\/jats:p><\/jats:sec><jats:sec><jats:title>Key results<\/jats:title><jats:p>A total of 751 of 764 (98.3%) patients completed follow\u2010up. The percentage of patients with ZAP was 12.4% at day 90, 7.1% at 6\u00a0months and 4.0% at 1\u00a0year. After the third month, the NRS were 3 or less in most of the remaining patients with ZAP. Stratified analysis revealed significant persistence of ZAP in patients aged \u226550\u00a0years and in those aged \u226565\u00a0years, and in patients with either moderate\u2010to\u2010severe skin symptoms or severe pain at the initial consultation. Stratified analyses unexpectedly showed patients who commenced famciclovir at 0\u20132\u00a0days after onset of the eruption had a higher prevalence of ZAP at day 90 than those treated at 3\u20135\u00a0days or \u22656\u00a0days after rash onset (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0164, log\u2010rank test). On further analysis, a higher proportion of patients (45.4%) treated at 0\u20132\u00a0days had moderate to severe symptoms compared with those treated at 3\u20135\u00a0days (40.5%) or \u22656\u00a0days (37.0%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0987, Cochran\u2010Armitage test).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion &amp; Inference<\/jats:title><jats:p>This study, with an exceptionally high follow\u2010up rate, revealed several new findings, including the influence of disease severity on the delay between the onset of symptoms and seeking medical attention. Six adverse drug reactions were reported in five of 721 patients in the safety analysis, including two severe cases of vomiting and convulsions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12379","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:23:47Z","timestamp":1393262627000},"page":"1716-1722","source":"Crossref","is-referenced-by-count":16,"title":["One\u2010year follow\u2010up of zoster\u2010associated pain in 764 immunocompetent patients with acute herpes zoster treated with famciclovir (FAMILIAR study)"],"prefix":"10.1111","volume":"28","author":[{"given":"S.","family":"Imafuku","sequence":"first","affiliation":[{"name":"Department of Dermatology Fukuoka University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukuoka University Fukuoka 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