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Several studies have demonstrated the influence of human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) genes on the susceptibility of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, highlighting the importance of certain alleles but, until today, no studies have evaluated the relationship between <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles and the prognosis of patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this retrospective cohort study was to evaluate the polymorphism of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I and class <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> alleles in a group of 46 <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> Caucasian patients, looking for their influence in susceptibility and prognosis of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Study population included a case\u2010cohort sample of 46 Caucasian patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> that, between 1993 and 1997, underwent <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> class I and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> genomic typing. All patients were diagnosed and followed up from 1977 to 2012 (mean follow\u2010up of 11\u00a0years) and they were divided into three groups according to the evolution of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Molecular typing at low\u2010resolution level revealed that <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*24, A*68, A*69, B*35 and <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05:02 alleles were involved in susceptibility to <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>. Correspondence analysis underlined that long\u2010lasting remission was characterized by <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*24 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*25 alleles, frequent relapse by <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*01, <jats:styled-content style=\"fixed-case\">DQA<\/jats:styled-content>1*01:01, <jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1*05:01 alleles and death by <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*68, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*08, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*35, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*03 alleles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that the prognosis of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> patients is not only correlated with clinical\/pathological\/serological\/immunological variables but it also relies on specific <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12391","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T13:01:23Z","timestamp":1392642083000},"page":"1732-1737","source":"Crossref","is-referenced-by-count":11,"title":["Immunogenetic factors in mycosis fungoides: can the <scp>HLA<\/scp> system influence the susceptibility and prognosis of the disease? 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