{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:39:46Z","timestamp":1791632386987,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Stringent control of proteolytic activity represents a major therapeutic approach for wound\u2010bed preparation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We tested whether a protease\u2010modulating polyacrylate\u2010 (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\u2010) containing hydrogel resulted in a more efficient wound\u2010bed preparation of venous leg ulcers when compared to an amorphous hydrogel without known protease\u2010modulating properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were randomized to the polyacrylate\u2010based hydrogel (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) or to an amorphous hydrogel (<jats:italic>n<\/jats:italic>\u00a0=\u00a041). Wound beds were evaluated by three blinded experts using photographs taken on days 0, 7 and 14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 14 days of treatment there was an absolute decrease in fibrin and necrotic tissue of 37.6\u00a0\u00b1\u00a029.9 percentage points in the <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\u2010based hydrogel group and by 16.8\u00a0\u00b1\u00a023.0 percentage points in the amorphous hydrogel group. The absolute increase in the proportion of ulcer area covered by granulation tissue was 36.0\u00a0\u00b1\u00a027.4 percentage points in the <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\u2010based hydrogel group and 14.5\u00a0\u00b1\u00a022.0 percentage points in the control group. The differences between the groups were significant (decrease in fibrin and necrotic tissue <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004 and increase in granulation tissue <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0005, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In particular, long\u2010standing wounds profited from the treatment with the <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\u2010based hydrogel. These data suggest that <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\u2010based hydrogel dressings can stimulate normalization of the wound environment, particularly in hard\u2010to\u2010heal ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12400","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T12:20:50Z","timestamp":1393417250000},"page":"1742-1750","source":"Crossref","is-referenced-by-count":41,"title":["Protease\u2010modulating polyacrylate\u2010based hydrogel stimulates wound bed preparation in venous leg ulcers \u2013 a randomized controlled trial"],"prefix":"10.1111","volume":"28","author":[{"given":"P.","family":"Humbert","sequence":"first","affiliation":[{"name":"Research and Studies Center on the Integument (CERT) Clinical Investigation Center (CIC BT506) Department of Dermatology University Hospital Besan\u00e7on France"},{"name":"INSERM UMR University of Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Faivre","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"V\u00e9ran","sequence":"additional","affiliation":[{"name":"Department of Dermatology H\u00f4pital d'Instructions des Arm\u00e9es A. 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