{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:16:27Z","timestamp":1763468187762},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The morphea\u2010type basal cell carcinoma (<jats:styled-content style=\"fixed-case\">MBCC<\/jats:styled-content>) is a rare form of basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) with lower response to treatments than other types of <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the role of radiotherapy (<jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>) in the therapeutic strategy of <jats:styled-content style=\"fixed-case\">MBCC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study was performed on 127 patients affected with MBCC, who underwent RT in the period 1982\u20132013. RT was delivered with conventional energies ranging from 50 to 120 <jats:styled-content style=\"fixed-case\">kV<\/jats:styled-content> and the administration of a total dose ranging from 40 to 70 Gy (mean 56.17\u00a0Gy). The irradiated fields included a margin of 1.5\u00a0cm around the lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up time was 29\u00a0months (range 1\u2013324\u00a0months). Complete remission was observed in 122 patients (96.06%), partial remission in one (0.78%). Three cases were non\u2010responsive (2.36%). In one case (0.78%), the lesion failed to heal after <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>, since the onset of radiodermatitis histologically ascertained. The cure rate was 81.08% after 5\u00a0years and 78.02% after 10\u00a0years from the end of <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>. Twelve cases relapsed (10.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Because of the frequent diagnostic delay and its ill\u2010defined margins, <jats:styled-content style=\"fixed-case\">MBCC<\/jats:styled-content> is difficult to cure. Our results after 5\u00a0years from <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> (cure rate 81.08%) are more satisfactory respect to the others reported in the literature (69% and 72.3%), but less good than those obtained in other forms of primary malignant neoplasms of the skin (92.43%). Nevertheless, we consider that <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content> plays an important role in the therapeutic strategy of <jats:styled-content style=\"fixed-case\">MBCC<\/jats:styled-content>s. In fact, it can be applied easily in elderly patients, and in peculiar localization of the disease (eyelid, nose and ear), without being invasive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12404","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T17:24:13Z","timestamp":1393262653000},"page":"1751-1755","source":"Crossref","is-referenced-by-count":10,"title":["Radiotherapy of morphea\u2010type basal cell carcinoma: results in 127 cases"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Caccialanza","sequence":"first","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Piccinno","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"\u00c7uka","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Alberti Violetti","sequence":"additional","affiliation":[{"name":"Servizio di Fotoradioterapia UO Dermatologia Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rozza","sequence":"additional","affiliation":[{"name":"UOS Fisica Sanitaria Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1986.tb01993.x"},{"key":"e_1_2_5_3_1","first-page":"233","article-title":"Radiotherapy of morphea\u2010type basal\u2010cell carcinomas","volume":"14","author":"Caccialanza M","year":"1999","journal-title":"Skin Cancer"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(04)93602-2"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30558.x"},{"key":"e_1_2_5_6_1","first-page":"691","article-title":"Metastatic basal cell carcinoma: is infiltrative\/morpheaform subtype a risk factor?","volume":"16","author":"Bozikov K","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2009.03.020"},{"key":"e_1_2_5_8_1","first-page":"1423","article-title":"Facial basal cell carcinoma: analysis of recurrence and follow\u2010up strategies","volume":"26","author":"Sartore L","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.11.009"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04767.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11798"},{"key":"e_1_2_5_12_1","first-page":"237","volume-title":"Statistics in medicine","author":"Colton T","year":"1974"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1951.01570010056004"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1988.tb03363.x"},{"key":"e_1_2_5_15_1","first-page":"373","article-title":"Sclerodermiform basal cell carcinoma. 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