{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:02:21Z","timestamp":1790622141799,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Drug reaction with eosinophilia and systemic symptoms (\n DRESS<\/jats:styled-content>\n ) may relapse following introduction of drugs structurally unrelated to the initial culprit drug.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To assess the frequency and characteristics of recurrent drug eruptions in patients with history of\n DRESS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients who had developed adverse cutaneous reaction after\n DRESS<\/jats:styled-content>\n occurrence were recruited from the regional database of Upper Normandy in France. Rate of recurrences were compared with patients with Toxic Epidermal Necrolysis (\n TEN<\/jats:styled-content>\n ) and Stevens\u2013Johnson syndrome (\n SJS<\/jats:styled-content>\n ) patients during the same time frame.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 60 cases of\n DRESS<\/jats:styled-content>\n collected, 15 (25%) with recurrences were retained for analysis. Seven patients had a single recurrence, whereas eight patients had several relapses. In the patients with pre\u2010existing\n DRESS<\/jats:styled-content>\n , recurrences were incomplete, corresponding to cutaneous rash in 13 cases and associated with eosinophilia in seven cases. Internal organ involvement was observed in two cases. In contrast, a single recurrence was found out of 61 patients with\n TEN<\/jats:styled-content>\n \/\n SJS<\/jats:styled-content>\n .<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Incomplete recurrences with structurally unrelated culprit drugs are a frequent phenomenon in\n DRESS<\/jats:styled-content>\n patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12419","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T10:07:15Z","timestamp":1394705235000},"page":"801-804","source":"Crossref","is-referenced-by-count":65,"title":["Recurrence of drug\u2010induced reactions in\n DRESS<\/scp>\n patients"],"prefix":"10.1111","volume":"29","author":[{"given":"D.","family":"Picard","sequence":"first","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"},{"name":"Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vellar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Janela","sequence":"additional","affiliation":[{"name":"Singapore Immunology Network Agency for Science Technology and Research A*STAR Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Roussel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Joly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"},{"name":"Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Musette","sequence":"additional","affiliation":[{"name":"Department of Dermatology Rouen University Hospital Rouen France"},{"name":"Inserm U905 Institute for Research and Innovation in Biomedicine Rouen University Hospital University of Normandy Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001116"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02788.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3498"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01832.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.04.007"},{"key":"e_1_2_6_8_1","first-page":"321","article-title":"Drug neosensitization during anticonvulsant hypersensitivity syndrome","volume":"16","author":"Gaig P","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_9_1","first-page":"293","article-title":"Multiple drug hypersensitivity\u2013proof of multiple drug hypersensitivity by patch and lymphocyte transformation tests","volume":"15","author":"Gex\u2010Collet C","year":"2005","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.138.8.1019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01518.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05021.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1684\/ejd.2010.0821","article-title":"Amoxicillin\u2010induced flare in patients with DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpes virus 6 replication in vitro","volume":"20","author":"Mardivirin L","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08167.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07238.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20295"}],"container-title":["Journal of the European Academy of Dermatology and 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