{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:17:47Z","timestamp":1761988667313,"version":"3.37.3"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Young Scientists","award":["25860925"],"award-info":[{"award-number":["25860925"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Food\u2010dependent exercise\u2010induced anaphylaxis (<jats:styled-content style=\"fixed-case\">FDEIA<\/jats:styled-content>) is a serious food allergy in which anaphylaxis develops when exercise is performed within several hours after food intake. The precise mechanism underlying allergic sensitization in <jats:styled-content style=\"fixed-case\">FDEIA<\/jats:styled-content> has been an important issue but remains poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to elucidate the pathomechanism including the route of allergen sensitization involved in <jats:styled-content style=\"fixed-case\">FDEIA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Japanese family with wheat\u2010dependent exercise\u2010induced anaphylaxis (<jats:styled-content style=\"fixed-case\">WDEIA<\/jats:styled-content>), a specific form of <jats:styled-content style=\"fixed-case\">FDEIA<\/jats:styled-content>, were clinically examined. Mutation analysis of the gene encoding filaggrin (<jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic>) was also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two of the family members were confirmed as <jats:styled-content style=\"fixed-case\">WDEIA<\/jats:styled-content> on the basis of their medical history and positive provocation test results. Notably, the two affected individuals in the family had concomitant ichthyosis vulgaris. Mutation analysis of <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> revealed that they carry one or more loss\u2010of\u2010function mutations that have not been described in the Japanese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results indicate that <jats:italic><jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content><\/jats:italic> mutations might be involved in the pathogenesis of <jats:styled-content style=\"fixed-case\">WDEIA<\/jats:styled-content> in the present case.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12441","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T08:13:14Z","timestamp":1394784794000},"page":"805-808","source":"Crossref","is-referenced-by-count":12,"title":["Loss\u2010of\u2010function mutations in the gene encoding filaggrin underlie a Japanese family with food\u2010dependent exercise\u2010induced anaphylaxis"],"prefix":"10.1111","volume":"29","author":[{"given":"O.","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Ohguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hokkaido University Graduate School of Medicine Sapporo 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