{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:49:17Z","timestamp":1788871757943,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cumdente GmbH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n The difficulty of antifungal substances to penetrate keratin and slow nail growth limit the efficacy of topical therapy in onychomycosis. One promising alternative is photodynamic antimicrobial chemotherapy, or\n PACT<\/jats:styled-content>\n : an irradiated photosensitizer creates singlet oxygen molecules which destroy pathogens without damaging human cells.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n As\n PACT<\/jats:styled-content>\n has demonstrated strong antifungal capabilities, we wanted to investigate its efficacy in an\n in vitro<\/jats:italic>\n model of onychomycosis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n PACT<\/jats:styled-content>\n was tested in a microdilution assay, in an\n in vitro<\/jats:italic>\n onychomycosis model as well as in a patient.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n PACT<\/jats:styled-content>\n inhibited fungal growth in the microdilution assay with no colonies of\n T. rubrum<\/jats:italic>\n detectable. Fungal growth was also inhibited in an onychomycosis model, after 30\u00a0min of\n LED<\/jats:styled-content>\n irradiation. Subsequently, a patient with distolateral onychomycosis was treated on three consecutive days and showed significant and durable improvement of nail morphology 6\u00a0months after.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n PACT<\/jats:styled-content>\n appears to be an effective treatment of onychomycosis\n in vitro<\/jats:italic>\n . The promising results need to be validated by clinical trials.\n <\/jats:p>\n \u00a0<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12467","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T07:58:40Z","timestamp":1395647920000},"page":"86-90","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of antifungal\n PACT<\/scp>\n in an\n in vitro<\/i>\n model of onychomycosis"],"prefix":"10.1111","volume":"29","author":[{"given":"T.","family":"Mehra","sequence":"first","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls\u2010University T\u00fcbingen Germany"},{"name":"\u00c4rztliche Direktion Abteilung Medizincontrolling Universit\u00e4tsSpital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Eberhard\u2010Karls\u2010University T\u00fcbingen 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