{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:01:44Z","timestamp":1769277704136,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico-CNPQ","award":["4668832562237534"],"award-info":[{"award-number":["4668832562237534"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The recurrence of American cutaneous leishmaniasis (<jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>) in patients experiencing a long\u2010term cure is often called leishmaniasis recidiva cutis (<jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> is considered an unusual form of <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to estimate the incidence of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> patients evaluated at a tertiary dermatologic centre in Midwestern Brazil. We also aim to evaluate the association between various treatment regimens and the development of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> using multivariate analysis in a case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a 17\u2010year epidemiological study using data from patients treated at our dermatologic centre from July 1994 to December 2011. A retrospective analysis was then performed to estimate risk and protective factors related to clinical presentation. We also assessed the influence of treatment regimens in the development of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> among <jats:styled-content style=\"fixed-case\">ACL<\/jats:styled-content> patients was 1.34%. The analysis included 105 patients; 82 patients (78%) were in the control group, and 23 patients (22%) were in the <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> case group. The data analysis indicated that the standard treatment N\u2010methylglucamine antimoniate (N\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>) reduced the development of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> in bivariate (odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>)\u00a0=\u00a00.34; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.13\u20130.91) and multivariate analyses (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.16; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.03\u20130.86; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). However, no differences in <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content> incidence were observed when the standard treatment N\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and alternative drugs, such as pentamidine and amphotericin B, were considered (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.47; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.16\u20131.35)<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that the standard treatment N\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>, as proposed by the Brazilian Ministry of Health, is effective in the prevention of <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content>. Although other drugs have shown promising results in <jats:styled-content style=\"fixed-case\">LRC<\/jats:styled-content>, more scientific evidence is needed to assess their efficacy compared with N\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12473","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T13:43:40Z","timestamp":1395409420000},"page":"109-114","source":"Crossref","is-referenced-by-count":6,"title":["The influence of treatment on the development of leishmaniasis recidiva cutis: a 17\u2010year case\u2013control study in Midwestern Brazil"],"prefix":"10.1111","volume":"29","author":[{"given":"C.M.","family":"Gomes","sequence":"first","affiliation":[{"name":"Department of Dermatology Universidade de Bras\u00edlia Bras\u00edlia Brazil"},{"name":"Laborat\u00f3rio de Dermatomicologia P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas Faculdade de Medicina Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.V.","family":"Cesetti","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.O.","family":"de Morais","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.T.","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Roselino","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medical Clinics University of S\u00e3o Paulo Ribeir\u00e3o Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.N.R.","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Dermatomicologia P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias M\u00e9dicas Faculdade de Medicina Universidade de Bras\u00edlia Bras\u00edlia Brazil"},{"name":"Department of Dermatology Department of Clinical Medicine Universidade de Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1993.tb02767.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02518.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2000.00004.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1309.061446"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-9292-6-3"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04419.x"},{"key":"e_1_2_5_8_1","first-page":"329","article-title":"Leishmaniose recidiva c\u00fatis causada por Leishmania Vianis braziliensis","volume":"71","author":"Costa JML","year":"1996","journal-title":"Anais Bras Dermatol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)91945-7"},{"key":"e_1_2_5_10_1","unstructured":"Brasil.Minist\u00e9rio da Sa\u00fade. Secretaria de Vigilancia em Saude. Manual de Vigilancia da Leishmaniose Tegumentar Americana\/Minist\u00e9rio da Sa\u00fade Secretaria de Vigil\u00e2ncia em Sa\u00fade 2 ed. atual.Editora do Minist\u00e9rio da Sa\u00fade Bras\u00edlia 2007."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-91992012000300012"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00687.x"},{"key":"e_1_2_5_13_1","first-page":"CD004834","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","volume":"2","author":"Gonz\u00e1lez U","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3147-3153.2003"},{"key":"e_1_2_5_15_1","unstructured":"Declaration of Helsinki World Medical Association. URLhttp:\/\/www.wma.net\/en\/30publications\/10policies\/b3\/(last accessed: 28 July 2013)."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/382135"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1998.58.824"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1086\/515355"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1086\/322643"},{"key":"e_1_2_5_20_1","first-page":"294","article-title":"Histopathological spectrum in cutaneous leishmaniasis: a study in Oman","volume":"67","author":"Venkataram M","year":"2001","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.58698"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20131885"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00190.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/524042"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/808132"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712799828300"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001667"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v24i4.1289"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-009-0485-0"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.02.007"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1179\/000349804X3171"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03086.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12473","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12473","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:00:03Z","timestamp":1695506403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,21]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jdv.12473"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12473","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,21]]}}}