{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:26:37Z","timestamp":1770333997793,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>China has a great variety of geographical and climatic conditions, and several cultural differences exist within the country; thus, understanding the regional and seasonal differences that cause skin sensitivities in this country is important.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess skin sensitivity of women from six cities in China and from South Korea during the winter and summer seasons to aid the development of suitable and effective dermatological products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicentre study included 754 healthy female volunteers, and was conducted in the winter (between January and March) and summer (between June and July) of 2011. Patch tests were performed using 0.5% sodium lauryl sulphate (<jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>) aqueous solution and 0.15% retinol in 1,3\u2010butylene glycol on the back of the volunteers. Simultaneously, stinging tests were performed on their cheeks by using 5% lactic acid solution and 0.001% capsaicin solution, each in a negative control vehicle (distilled water and 10% ethanol solution, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patch test results showed that the subjects in Beijing and Shenyang were more sensitive to <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>, retinol and lactic acid in the winter than were those in Guangzhou, Shanghai, Wuhan, Chengdu and South Korea. The stinging test results revealed that the subjects in Beijing were more neurosensitive to lactic acid in the winter; however, during the same season, the subjects from Shanghai and Guangzhou were significantly more neurosensitive to capsaicin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our observations indicate that skin sensitivity differs considerably between women from different parts of China and South Korea. We recommend that these differences be considered during the development of cosmetic products in these countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12482","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T12:06:22Z","timestamp":1395749182000},"page":"115-119","source":"Crossref","is-referenced-by-count":9,"title":["Regional and seasonal differences in skin irritation and neurosensitivity in Chinese and South Korean women"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Oh","sequence":"first","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010A.","family":"Cho","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010H.","family":"Yeon","sequence":"additional","affiliation":[{"name":"AmorePacific Corporation Shanghai R&amp;I Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q.\u2010Q.","family":"He","sequence":"additional","affiliation":[{"name":"AmorePacific Corporation Shanghai R&amp;I Center Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The General Hospital of the Air Force Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010M.","family":"Wang","sequence":"additional","affiliation":[{"name":"Skin &amp; Cosmetic Research Department Shanghai Skin Disease Hospital Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Venereology West China Hospital Sichuan University Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Third Affiliated Hospital of Sun Yat\u2010Sen University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Renmin Hospital of Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.\u2010H.","family":"Gao","sequence":"additional","affiliation":[{"name":"National Key Department of Dermatology and Venereology The First Hospital of China Medical University Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Shin","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"An","sequence":"additional","affiliation":[{"name":"Skin Research Institute AmorePacific Corporation R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231524"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000159772"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12042"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2003.00026.x"},{"key":"e_1_2_5_6_1","first-page":"197","article-title":"A method for appraising the stinging capacity of topically applied substances","volume":"28","author":"Frosch PJ","year":"1977","journal-title":"J Cosmet Chem"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00016.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047989"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2000.006002070.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00754.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.03.007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12069"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2011.00639.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12482","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:59:33Z","timestamp":1695506373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/jdv.12482"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12482","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}