{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:29:52Z","timestamp":1781900992891,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Brazilian Center for Studies in Dermatology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Post\u2010inflammatory hyperpigmentation is a frequent concern when treating solar lentigines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the safety and efficacy of a triple combination cream with fluocinolone acetonide 0.01%, hydroquinone 4% and tretinoin 0.05% as adjuvant to cryotherapy in the treatment of solar lentigines in hands dorsum, and in the prevention of post\u2010inflammatory hyperpigmentation after cryotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, randomized, controlled, investigator\u2010blinded, single\u2010centre study enrolled 50 patients. Twenty\u2010five patients received a 2\u2010week daily triple combination cream plus sunscreen pre\u2010treatment and 25 received sunscreen alone. After that, cryotherapy was performed in all patients followed by a 3\u2010week recovery period. After this period, patients received the same initial treatment and were followed up for 8\u00a0weeks. Melanin and erythema levels of a target and a control lentigo were objectively measured using a narrowband reflectance spectrophotometer. Lentigines count, colour homogeneity and global improvement were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The number of solar lentigines reduced in the first 2\u00a0weeks only in patients who used the triple combination 25\u00a0\u00b1\u00a07 vs. 22\u00a0\u00b1\u00a08 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), and reduced at the end of the study for both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The melanin levels also reduced in the first 2\u00a0weeks only in patients who used the triple combination 297\u00a0\u00b1\u00a069 vs. 273\u00a0\u00b1\u00a066 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and reduced at the end of the study for both groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Erythema and residual blisters from cryotherapy were the reported adverse reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Triple combination cream can be used to enhance the resolution of solar lentigines, and to significantly reduce melanin levels and lentigines count, improving treatment results. It was well\u2010tolerated and did not increase the occurrence of neither erythema nor other side\u2010effects after the cryotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12484","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T13:26:58Z","timestamp":1396272418000},"page":"128-133","source":"Crossref","is-referenced-by-count":9,"title":["Triple combination as adjuvant to cryotherapy in the treatment of solar lentigines: investigator\u2010blinded, randomized clinical trial"],"prefix":"10.1111","volume":"29","author":[{"given":"D.","family":"Hexsel","sequence":"first","affiliation":[{"name":"Brazilian Center for Studies in Dermatology Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hexsel","sequence":"additional","affiliation":[{"name":"Brazilian Center for Studies in Dermatology Porto Alegre 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