{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:14:03Z","timestamp":1771640043569,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a perpetuating increase in melanoma and basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) incidence in Europe. Few studies are evaluating various risk factors for both tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This pre\u2010planned additional analysis directly compared occupational and past\u2010time ultraviolet exposure behaviour, and examined the effects of sun sensitivity between melanoma and sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, and assessed its importance for the two entities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The study included 503 patients (melanoma, <jats:italic>n<\/jats:italic>\u00a0=\u00a0291 and <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a0212), and 329 controls from Germany. In all, 244 (49%) of the cases and 165 (50%) of the controls were male (median age melanoma, 55\u00a0years; <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, 69\u00a0years; and controls, 57\u00a0years). Selection of important risk factors was performed by backward elimination in a polytomous logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When directly comparing melanoma and sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, actinic elastosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 48.83; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 17.87, 133.40) and site were associated with a higher risk of melanoma, whereas mountaineering in childhood, sunburn 20\u00a0years before diagnosis, farming full time, sunbed use in general, seborrheic keratosis, actinic cheilitis, actinic keratosis and age were associated with a higher risk of sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>. Gardening 20\u00a0years before melanoma, hair colour and solar lentigo were risk factors for both entities. A re\u2010evaluation of the data excluding lentiginous melanoma entities (i.e. acro\u2010lentiginous and lentigo\u2010maligna melanoma) resulted in selection of the same factors. However, compared to controls, atopy evolved as a protective factor for melanoma (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.29; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.15, 0.57) and <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.41; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.17, 0.99), respectively, but was associated with a higher risk of sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> compared to melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The odds for having clinical actinic elastosis was lower in <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> compared to melanoma. In contrast, various factors associated with chronic <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> exposure and age had higher odds for sporadic <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, rather than melanoma. Further research is required to set the context for these findings, especially regarding, atopy in non\u2010lentiginous vs. lentiginous forms of melanoma, and possible molecular pathways involved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12488","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T11:02:30Z","timestamp":1396263750000},"page":"134-142","source":"Crossref","is-referenced-by-count":28,"title":["Ultraviolet exposure and risk of melanoma and basal cell carcinoma in Ulm and Dresden, Germany"],"prefix":"10.1111","volume":"29","author":[{"given":"P.","family":"Kaskel","sequence":"first","affiliation":[{"name":"Vaterstetten Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Dermatology Technical University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sander","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry University of Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.","family":"Huber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulm Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Utikal","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Ulm Ulm Germany"},{"name":"Skin Cancer Unit German Cancer Research Center (DKFZ) Heidelberg Germany"},{"name":"Department of Dermatology, Venereology and Allergology University Medical Center Mannheim Ruprecht\u2010Karl University of Heidelberg Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Leiter","sequence":"additional","affiliation":[{"name":"Department of 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