{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:25:15Z","timestamp":1788870315904,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Spanish Medicines and Health Products Agency"},{"name":"Abbott\/Abbvie"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MSD"},{"name":"Janssen"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Biobadaderm is the Spanish registry of psoriasis patients receiving systemic treatment in clinical practice.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To compare the safety of biologics and classic systemic treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Prospective cohort of patients receiving biologics and classic systemic therapies between 2008 and 2013 in 12 hospitals are included. We registered demographic data, diagnoses, comorbidities, treatments and adverse events (\n AE<\/jats:styled-content>\n ). We obtained raw relative risks (RR) for specific\n AE<\/jats:styled-content>\n . Multivariate analysis consisted of Cox models adjusting for age, gender, chronic hepatic disease and previous cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 1030 patients received biologics (2061\n AE<\/jats:styled-content>\n in 3681 person\u2010years), 926 patients classic systemic drugs (1015\n AE<\/jats:styled-content>\n in 1517 person\u2010years). Ninety\u2010three per cent of\n AE<\/jats:styled-content>\n in both groups were non\u2010serious, 6% serious and 0.003% fatal. The age\u2010 and gender\u2010adjusted hazard ratio of\n AE<\/jats:styled-content>\n was lower in the biologics group [hazard ratio 0.6 (95% CI: 0.5\u20130.7)].We found no differences in rates of serious and mortal\n AE<\/jats:styled-content>\n . Some system organ class\n AE<\/jats:styled-content>\n rates differed between both groups. As limitations: Prescription bias might affect the incidence of\n AE<\/jats:styled-content>\n in both groups. Association of drug and\n AE<\/jats:styled-content>\n was based on timing: associations might not be causal.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Patients receiving biologics had lower risk of\n AE<\/jats:styled-content>\n . We did not find differences in the risk of serious or fatal\n AE<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12492","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T07:02:54Z","timestamp":1396249374000},"page":"156-163","source":"Crossref","is-referenced-by-count":56,"title":["Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5\u2010year observational study of clinical practice: 2008\u20132013 results of the Biobadaderm registry"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Carretero","sequence":"first","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr Negr\u00edn Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ferrandiz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Dauden","sequence":"additional","affiliation":[{"name":"Hospital Universitario la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vanaclocha Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.J.","family":"G\u00f3mez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Herrera\u2010Ceballos","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen de la Victoria M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"De la Cueva\u2010Dobao","sequence":"additional","affiliation":[{"name":"Hospital Infanta Leonor Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Belinch\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Alicante Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"S\u00e1nchez\u2010Carazo","sequence":"additional","affiliation":[{"name":"Hospital General Universitario de Valencia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alsina\u2010Gibert","sequence":"additional","affiliation":[{"name":"Hospital Clinic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.L.","family":"L\u00f3pez\u2010Estebaranz","sequence":"additional","affiliation":[{"name":"Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ferr\u00e1n","sequence":"additional","affiliation":[{"name":"Hospital del Mar Parc de Salut Mar Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Torrado","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Gran Canaria Dr Negr\u00edn Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Hospital Universitario Germans Trias i Pujol Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carazo","sequence":"additional","affiliation":[{"name":"Hospital Universitario la Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rivera","sequence":"additional","affiliation":[{"name":"Hospital Universitario 12 de Octubre Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jim\u00e9nez\u2010Puya","sequence":"additional","affiliation":[{"name":"Hospital Universitario Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Garc\u00eda\u2010Doval","sequence":"additional","affiliation":[{"name":"Research Unit. 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