{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:55:51Z","timestamp":1774342551010,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although facial hyperhidrosis has been frequently associated with a diminished quality of life, various conservative modalities for its management are still far from satisfactory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the antiperspirant efficacy and safety of the topical glycopyrrolate on facial hyperhidrosis at specified posttreatment intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine patients with facial hyperhidrosis were enrolled and treated with 2% topical glycopyrrolate on one\u2010half of the forehead, whereas the other half of the forehead was treated with a placebo. All patients applied topical glycopyrrolate or placebo once a day for nine successive days. Each evaluation included weighing sweat and assessing the Hyperhidrosis Disease Severity Scale (<jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content>) score and any adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the placebo\u2010treated sides, topical glycopyrrolate\u2010treated sides showed a reduction in the rate of sweat production at the forehead of 25.16\u00a0\u00b1\u00a010.30% (mean\u00a0\u00b1\u00a0SD) at 90\u00a0min after the first application (day 1), 29.63\u00a0\u00b1\u00a07.74% at 24\u00a0h after the first application (day 2) and 36.68\u00a0\u00b1\u00a011.41% at 24\u00a0h after eight additional successive daily applications (day 10) (all <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.025). There was a little more decrease in <jats:styled-content style=\"fixed-case\">HDSS<\/jats:styled-content> score with the topical glycopyrrolate\u2010treated half of the forehead, but the difference was not statistically significant (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.025). No serious adverse events were reported during the course of this study. Only one patient developed a transient headache after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical glycopyrrolate application appears to be significantly effective and safe in reducing excessive facial perspiration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12518","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:05:43Z","timestamp":1402311943000},"page":"278-282","source":"Crossref","is-referenced-by-count":32,"title":["Efficacy and safety of topical glycopyrrolate in patients with facial hyperhidrosis: a randomized, multicentre, double\u2010blinded, placebo\u2010controlled, split\u2010face study"],"prefix":"10.1111","volume":"29","author":[{"given":"M.Y.","family":"Hyun","sequence":"first","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.P.","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.G.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.Y.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chung\u2010Ang University College of Medicine Seoul 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