{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:10Z","timestamp":1788871810387,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,7,27]],"date-time":"2014-07-27T00:00:00Z","timestamp":1406419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consultant contract with LEO Pharmaceutical"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Topical therapy is important in the treatment of actinic keratosis (\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      ), a major risk factor for, and early development stage of, squamous cell carcinoma. Despite this, research addressing the limitations and challenges associated with topical field therapy in actinic keratosis is lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this study was to highlight the challenges associated with maximizing compliance in patients receiving topical\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      therapy and to investigate real\u2010world experience with currently available topical therapies including perceptions of adherence and persistence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 45\u2010min online survey was developed and completed by physicians in eight countries. All had previously prescribed topical\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      therapy and \u22651 other treatment. Physicians' consensus was summarized as overall agreement\/disagreement from \u226570% of respondents (\u226560% for case\u2010specific questions).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>More than 70% of the 427 respondents agreed that topical field therapy is essential and had concerns that lengthy treatments and local skin reactions caused non\u2010adherence\/persistence. More than 90% of physicians would preferentially prescribe the shortest duration treatment to such patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The research clarifies the challenges associated with prescribing topical\n                      <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>\n                      therapy and highlights that short treatment duration and rapid clearance of skin reactions are key considerations for physicians. This provides a basis for the generation of recommendations for improving the real\u2010world efficacy of topical therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12530","type":"journal-article","created":{"date-parts":[[2014,7,27]],"date-time":"2014-07-27T23:57:14Z","timestamp":1406505434000},"page":"298-306","source":"Crossref","is-referenced-by-count":21,"title":["Physician perceptions and experience of current treatment in actinic keratosis"],"prefix":"10.1111","volume":"29","author":[{"given":"E.","family":"Stockfleth","sequence":"first","affiliation":[{"name":"Charit\u00e9 University Hospital Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Peris","sequence":"additional","affiliation":[{"name":"Department of Dermatology Catholic University of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Guillen","sequence":"additional","affiliation":[{"name":"Instituto Valenciano de Oncologia Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cerio","sequence":"additional","affiliation":[{"name":"Skin Centre Barts and The London NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Basset\u2010Seguin","sequence":"additional","affiliation":[{"name":"Hopital Saint\u2010Louis Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Foley","sequence":"additional","affiliation":[{"name":"Department of Medicine (Dermatology) The University of Melbourne St Vincent's Hospital Melbourne and Skin &amp; Cancer Foundation Inc Carlton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Universidade de Sao Paulo Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Culshaw","sequence":"additional","affiliation":[{"name":"Adelphi Research Bollington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Erntoft","sequence":"additional","affiliation":[{"name":"Leo Pharma A\/S Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lebwohl","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,27]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06318.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11085.x"},{"key":"e_1_2_5_4_1","first-page":"715","article-title":"The relationship between occupational sun exposure and non\u2010melanoma skin cancer: clinical basics, epidemiology, occupational disease evaluation, and prevention","volume":"109","author":"Fartasch M","year":"2012","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02560.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.052"},{"key":"e_1_2_5_7_1","unstructured":"StockflethE TerhorstD BraathenLet\u00a0al.Guideline on Actinic Keratoses(2010). 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