{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:30:16Z","timestamp":1780921816458,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"s5","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Palmoplantar pustular psoriasis (PPPP) is a variant of psoriasis whose the association with psoriatic arthritis (PsA) has been recently described. There is limited evidence regarding how to best reduce palmoplantar pustular psoriasis severity and to maintain remission once achieved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to elaborate evidence\u2010based recommendations for PPPP treatment supported by a systematic literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search was carried out in Embase, Medline and Cochrane Library databases from 1980 to February 2013 searching for any trial in patients with PPPP assessing therapeutic interventions not including a systemic biotherapy. The selection of articles was limited to human subjects and English or French languages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 675 articles identified, 29 including one Cochrane review were analysed. The Cochrane review summarised 23 randomised controlled trials (RCTs) in chronic PPPP until February 2003, including 724 patients. The authors concluded that oral retinoid therapy (acitretin), photochemotherapy or combination of both, low dose of ciclosporin or topical corticosteroids under occlusion appeared to be helpful in relieving symptoms of PPPP. Since the publication of this review, 9 open studies on PPPP treatment have been published. Three new studies evaluated the benefits of PUVA on PPPP. They all showed a better efficacy of PUVA compared to UVB therapy. One open study concluded that a retinoid treatment with an arotinoid ethylesther showed a good efficacy. Five prospective studies (level of evidence of 3) assessed Laser Excimer UVB\u2010NB (Excimer 308 nm) in PPPP. The combined analysis of these studies showed that 64% of patients experienced an improvement of 70% at the end of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Phototherapy, ciclosporin and topical corticosteroids seem to be able to control PPPP. However, the standard of care for PPPP remains an issue and there is a strong need for reliable RCTs to better define treatment strategies for PPPP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12561","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T07:54:27Z","timestamp":1404287667000},"page":"13-16","source":"Crossref","is-referenced-by-count":61,"title":["Treatment for palmoplantar pustular psoriasis: systematic literature review, evidence\u2010based recommendations and expert opinion"],"prefix":"10.1111","volume":"28","author":[{"given":"M.","family":"Sevrain","sequence":"first","affiliation":[{"name":"Dermatology Department Morvan University Hospital Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010A.","family":"Richard","sequence":"additional","affiliation":[{"name":"Aix\u2010Marseille University UMR 911 INSERM CRO2 Assistance Publique and Dermatology Department Timone Hospital Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Barnetche","sequence":"additional","affiliation":[{"name":"Rheumatology Department Bordeaux University Hospital Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rouzaud","sequence":"additional","affiliation":[{"name":"Dermatology Department CHU Bordeaux University Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.P.","family":"Villani","sequence":"additional","affiliation":[{"name":"Dermatology Department Lyon University Edouard Herriot Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Paul","sequence":"additional","affiliation":[{"name":"Dermatology Department Paul Sabatier University UMR CNRS 5165 INSERM 1056 Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Beylot\u2010Barry","sequence":"additional","affiliation":[{"name":"Dermatology Department CHU Bordeaux University Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Jullien","sequence":"additional","affiliation":[{"name":"Dermatology Department Lyon University Edouard Herriot Hospital Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Aractingi","sequence":"additional","affiliation":[{"name":"Dermatology Department Cochin Tarnier Hospital APHP Paris 5 Descartes University INSERM UMR S 938 UPMC CDR Saint\u2010Antoine Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Aubin","sequence":"additional","affiliation":[{"name":"Dermatology Department Besan\u00e7on University Hospital and University of Franche\u2010Comt\u00e9 Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Joly","sequence":"additional","affiliation":[{"name":"Clinique Dermatologique Rouen University Hospital Inserm U905 Institute for Research and Innovation in Biomedicine (IRIB) Rouen University Normandy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Le Maitre","sequence":"additional","affiliation":[{"name":"Dermatologist (private practice) Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cantagrel","sequence":"additional","affiliation":[{"name":"Rheumatology Center Purpan Teaching Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010P.","family":"Ortonne","sequence":"additional","affiliation":[{"name":"Dermatology Department Nice University L'Archet II Hospital Nice France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Misery","sequence":"additional","affiliation":[{"name":"Dermatology Department Morvan University Hospital Brest France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"CD001433","article-title":"Interventions for chronic palmoplantar pustulosis","volume":"1","author":"Marsland AM","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12223"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12560"},{"key":"e_1_2_5_5_1","unstructured":"Oxford Center for Evidence\u2010Based Medicine: levels of evidence.http:\/\/www.cebm.net\/index.aspx?o=1025(last accessed: 9 March 2014)"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00306.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00196.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.06.016"},{"key":"e_1_2_5_9_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1684\/ejd.2009.0727","article-title":"Treatment of palmoplantar pustulosis with arotinoid ethylester","volume":"19","author":"Shan SJ","year":"2009","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01316.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2011.564769"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2008.2317"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2008.00364.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06320.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T03:54:20Z","timestamp":1694490860000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":13,"journal-issue":{"issue":"s5","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/jdv.12561"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12561","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}