{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:32Z","timestamp":1790396612492,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an acquired depigmentaion of skin and hair. The presence of white hair within vitiligo lesions is considered a bad prognostic sign since these lesions are difficult to repigment. Melanocyte reservoir was not extensively studied in vitiliginous white hair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate pigment cell reservoir in vitiliginous black and white hair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Using immunohistochemical technique, skin biopsies from 30 vitiligo patients (including either black or white hair) and 10 age\u2010 and gender\u2010matched healthy subjects were examined. Human Melanoma Black\u201045 (<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045) was used for detecting active melanocytes and Tyrosinase Related Protein 2 (<jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>2) for detecting the whole melanocyte lineage including melanocyte stem cells (MelSC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 61.1% of black hair was positive for <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 and 83.3% was positive for <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>2. About 25% of white hair was positive for <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 and 75% retained <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>2 positivity. Follicular <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 expression and <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>2 expression percentage were significantly lower in white than black hair (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.05, 0.04 respectively). Epidermal <jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>\u201045 and <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>2 expression percentages were significantly higher in lesions containing black rather than white hair (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.05 respectively). Black hair was significantly associated with histologically pigmented hair follicles (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.049), and with residual interfollicular melanin pigment (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Melanocytes, either active (melanotic) or inactive (amelanotic which may include MelSC), are not totally absent from vitiliginous white hair. However, intact melanocyte reservoir was observed more in black than white hair. This may add avenues for future research about the possibility of white vitiliginous hair to repigment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12573","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:07:45Z","timestamp":1402312065000},"page":"444-451","source":"Crossref","is-referenced-by-count":12,"title":["Immunohistochemical evaluation of vitiliginous hair follicle melanocyte reservoir: is it retained?"],"prefix":"10.1111","volume":"29","author":[{"given":"I.","family":"Seleit","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Andrology and STDs Menoufiya University Shebein Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.A.","family":"Bakry","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Andrology and STDs Menoufiya University Shebein Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.G.","family":"Abdou","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pathology Menoufiya University Shebein Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.M.","family":"Dawoud","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Andrology and STDs Menoufiya University Shebein Elkom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/416854a"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00855.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08818.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32210.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-007-0028-0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2008.00514.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/2009-0717-RAR.1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03233.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2002.1o049.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01504.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2008.11.016"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2004.05787.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913123.2013.870274"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03710.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.21000"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00651.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2007.00423.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04215.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2014.01.002"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200509084"},{"key":"e_1_2_7_22_1","first-page":"609","article-title":"The Notch pathway: hair graying and pigment cell homeostasis","volume":"23","author":"Schouwey K","year":"2008","journal-title":"Histol Histopathol"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.57604"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10113.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-2007-34-505"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)01484-1"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114752"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12573","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:33:35Z","timestamp":1695566015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,9]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jdv.12573"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12573","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,9]]}}}