{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:55:40Z","timestamp":1774976140641,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:00:00Z","timestamp":1406678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical studies regarding complete cure rate of onychomycosis using oral Terbinafine have a very broad range (14\u201390%) based solely on response to treatment on the big toenail.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the efficacy of Terbinafine in all affected onychomycotic toenails and, furthermore, to evaluate differences in mycological, clinical and complete cure rate between affected onychomycotic toenails.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Inclusion criteria are as follows: distolateralsubungual onychomycotic involvement of the hallux and additional involvement of at least two more toenails of the same foot. Exclusion criteria are as follows: patients with nail traumata and hypersensitivity to Terbinafine. Patients were treated with oral Terbinafine 250\u00a0mg\/day for 16\u00a0weeks. Mycological analysis was performed using direct microscopy and culture. Clinical improvement was assessed using digital photography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant difference was found in clinical improvement between the great toenail and all other involved toenails. The rate of complete cure (100% clinical cure and mycological cure) of the big toenail was lower (23%) as compared to the second (65%), third (51%) and the fourth toenail (67%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This is a case series study that was based on a single\u2010centre cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results support findings that efficacy of Terbinafine should be based on all involved onychomycotic toenails; the big toenail is not superior in response compared to other affected toenails.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12609","type":"journal-article","created":{"date-parts":[[2014,7,31]],"date-time":"2014-07-31T03:20:26Z","timestamp":1406776826000},"page":"521-526","source":"Crossref","is-referenced-by-count":8,"title":["Clinical comparison and complete cure rates of terbinafine efficacy in affected onychomycotic toenails"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Shemer","sequence":"first","affiliation":[{"name":"Department of Dermatology Chaim Sheba Medical Center Sackler School of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sakka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chaim Sheba Medical Center Sackler School of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Baran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nail Disease Centre University of Franche\u2010Comt\u00e9 Cannes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Scher","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Physicians and Surgeons Columbia University New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Amichai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Meir Medical Center Kfar Saba Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Norman","sequence":"additional","affiliation":[{"name":"Tel Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Farhi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculdade Tecnico Educacional Souza Marques Santa Casa da Misericordia do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Magun","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Health Sciences Soroka Medical Center Ben\u2010Gurion University of the Negev Beer\u2010Sheva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Brazilai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chaim Sheba Medical Center Sackler School of Medicine Tel\u2010Aviv University Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Medicine (Dermatology) University of Mississippi Oxford USA"},{"name":"Department of Dermatology University of Alabama Birmingham Birmingham USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,30]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"58","article-title":"Management of onychomycosis: a North American perspective","volume":"3","author":"Scher RK","year":"1997","journal-title":"Dermatol Ther"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00349.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1999.tb00837.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500420183"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1989.tb02192.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.730"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160713"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04825.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01678.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7190.1031"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05242.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6835.1151"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91815-9"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70111-7"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.7010.919"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1997.tb00505.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90187-6"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.12.019"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00988.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.415"},{"key":"e_1_2_5_22_1","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1001\/archderm.1995.01690200057011","article-title":"Treatment of toenail onychomycosis: a randomized, double\u2010blind study with terbinafine and griseofulvin","volume":"131","author":"Hofmann H","year":"1995","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.6661651.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91454-4"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017905"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.267"},{"key":"e_1_2_5_27_1","first-page":"919","article-title":"Short\u2010duration treatment of fingernail dermatophytosis","volume":"131","author":"Hofmann H","year":"1995","journal-title":"Arch Dermatol"},{"issue":"10","key":"e_1_2_5_28_1","first-page":"1194","article-title":"Fifth toenail clinical response to systemic antifungal therapy is not a marker of successful therapy for other toenails with onychomycosis","volume":"20","author":"Shemer A","year":"2006","journal-title":"J EurAcad Dermatol"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04699.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03426.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:34:30Z","timestamp":1695566070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,30]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/jdv.12609"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12609","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,30]]}}}