{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:17:01Z","timestamp":1791389821517,"version":"4.3.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Limited evidence is available on the effectiveness of treatments alternative to corticosteroids for vulvar lichen sclerosus (VLS). The present study aimed to assess the efficacy and tolerability of avocado and soybean extracts (ASE) as active principles of both a topical product and a nutritional supplement in the treatment of active mild\u2010to\u2010moderate VLS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Twenty\u2010three patients were enrolled. Treatment consisted of a topical product containing ASE and other lenitive and anti\u2010oxidant principles administered twice daily for 24\u00a0weeks, in association with a dietary supplement containing ASE, vitamin E and para\u2010aminobenzoic acid for the first 12\u00a0weeks. The primary efficacy endpoint was the rate of patients achieving an improvement from baseline in global subjective score (GSS) and global objective score (GOS) of \u2265 75%. Secondary efficacy endpoint was the rate of patients achieving GSS50 and GOS50. Tertiary efficacy endpoint was the mean reduction in subjective and objective scores throughout the treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By the end of the 24\u2010week treatment, 12 (70.5% of symptomatic patients) and 13 patients (72.2%) achieved an improvement of at least 75% in subjective and objective global scores, respectively; 100% and 88.9% reached GSS50 and GOS50, respectively. Mean symptom and sign scores decreased significantly after treatment. The treatment was well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results provide evidence that the topical and dietary supplements used in the study, which contain active principles exerting anti\u2010inflammatory, anti\u2010fibrotic, emollient and lenitive actions, are effective alternatives in the treatment of symptoms and signs of mild\u2010to\u2010moderate VLS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12617","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T10:09:34Z","timestamp":1409738974000},"page":"1225-1230","source":"Crossref","is-referenced-by-count":14,"title":["Avocado and soybean extracts as active principles in the treatment of mild\u2010to\u2010moderate vulvar lichen sclerosus: results of efficacy and tolerability"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Borghi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Corazza","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Minghetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Toni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Virgili","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche, Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356163"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.044"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09997.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12910"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12273"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0171"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.011"},{"key":"e_1_2_6_9_1","first-page":"1235","article-title":"\u201cAntisclerotic\u201d therapy of scleroderma: insaponifiable oils of avocado and soya. 50 clinical applications of H. 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