{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:34:38Z","timestamp":1789079678314,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 may be involved in angiogenesis in psoriasis and psoriatic arthritis (PsA). High\u2010resolution power Doppler ultrasound (<jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content>) can detect angiogenesis of synovium in PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 in psoriasis patients with or without PsA, and to correlate its levels with disease activity and high\u2010resolution <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content> findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, 48 patients with psoriasis (26 of them also had PsA) and 30 controls were assessed by high\u2010resolution <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content>, and assayed for serum levels of <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>. Patients were clinically assessed using Composite Psoriatic Disease Activity Index (<jats:styled-content style=\"fixed-case\">CPDAI<\/jats:styled-content>). Total joint score (<jats:styled-content style=\"fixed-case\">TJS<\/jats:styled-content>) was used to assess joint involvement in PsA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant elevation was found in <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels in psoriatics with or without PsA compared with controls (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), as well as in PsA (group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) compared to patients without arthritis (group I) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.002). <jats:styled-content style=\"fixed-case\">CPDAI<\/jats:styled-content>, synovial thickness score and colour Doppler ultrasound (<jats:styled-content style=\"fixed-case\">CDUS<\/jats:styled-content>) score were highly significantly higher in group II vs. group I (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In all patients, <jats:styled-content style=\"fixed-case\">CPDAI<\/jats:styled-content>, synovial thickness and <jats:styled-content style=\"fixed-case\">CDUS<\/jats:styled-content> score were positively correlated to each other, and each of them was positively correlated to serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). In either group I or <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 levels correlated positively with <jats:styled-content style=\"fixed-case\">CPDAI<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). In group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TJS<\/jats:styled-content>, synovial thickness and <jats:styled-content style=\"fixed-case\">CDUS<\/jats:styled-content> score were positively correlated to each other (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Serum <jats:styled-content style=\"fixed-case\">YKL<\/jats:styled-content>\u201040 can be used as a new biological marker for angiogenesis and disease activity in psoriasis with or without PsA. High\u2010resolution <jats:styled-content style=\"fixed-case\">PDUS<\/jats:styled-content> is a non\u2010invasive tool for the evaluation of angiogenesis in PsA patients as well as for the detection of early synovial changes in psoriasis patients without arthritis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12653","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T04:22:50Z","timestamp":1407126170000},"page":"682-688","source":"Crossref","is-referenced-by-count":17,"title":["Serum <scp>YKL<\/scp>\u201040 in psoriasis with and without arthritis; correlation with disease activity and high\u2010resolution power Doppler ultrasonographic joint findings"],"prefix":"10.1111","volume":"29","author":[{"given":"S.F.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Physical Medicine, Rheumatology, and Rehabilitation Faculty of Medicine Ain Shams University Cairo 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