{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:55:31Z","timestamp":1791561331646,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and objectives<\/jats:title>\n \n Reticular erythematous mucinosis (\n REM<\/jats:styled-content>\n ) and lupus erythematosus tumidus (\n LET<\/jats:styled-content>\n ) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of\n REM<\/jats:styled-content>\n and\n LET<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We evaluated epidermal thickness, hyperkeratosis, dermo\u2010epidermal junction changes, interstitial mucin deposition, vessel dilatation and pattern, type and density of the inflammatory infiltrate in 25 cases of\n REM<\/jats:styled-content>\n and\n LET<\/jats:styled-content>\n . Anti\u2010\n CD<\/jats:styled-content>\n 3, anti\u2010\n CD<\/jats:styled-content>\n 20, anti\u2010\n CD<\/jats:styled-content>\n 68, anti\u2010\n CD<\/jats:styled-content>\n 4, anti\u2010\n CD<\/jats:styled-content>\n 8, anti\u2010\n CD<\/jats:styled-content>\n 123, anti\u2010\n CD<\/jats:styled-content>\n 2\n AP<\/jats:styled-content>\n , anti\u2010IgG and anti\u2010C3 antibodies were tested in a subset of patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both diseases are characterized by perivascular dermal infiltrates of lymphocytes mainly\n CD<\/jats:styled-content>\n 4+ positive and increased dermal mucin. However,\n REM<\/jats:styled-content>\n tended to show more scattered and more superficial lymphocytes with more superficial mucin and to have less frequent immunoglobulin and complement depositions along the dermo\u2010epidermal junction. Plasmacytoid dendritic cells (\n PDC<\/jats:styled-content>\n s) were less represented in\n REM<\/jats:styled-content>\n , and were mainly found as single cells differently from\n LET<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n REM<\/jats:styled-content>\n and\n LET<\/jats:styled-content>\n present some differences in the infiltrate, including\n PDC<\/jats:styled-content>\n s, the mucin deposition and the immunoreactant deposition at the dermo\u2010epidermal junction that justify the distinction of the two diseases and suggest different pathogenetic mechanisms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12654","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:23:01Z","timestamp":1407111781000},"page":"689-697","source":"Crossref","is-referenced-by-count":39,"title":["Reticular erythematous mucinosis: histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus"],"prefix":"10.1111","volume":"29","author":[{"given":"E.","family":"Cinotti","sequence":"first","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DISSAL) University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"},{"name":"Section of Dermatology University Hospital of Saint\u2010Etienne Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Merlo","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DISSAL) University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kempf","sequence":"additional","affiliation":[{"name":"Kempf and Pfaltz Histological Diagnostics and Department of Dermatology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Carli","sequence":"additional","affiliation":[{"name":"Department of Surgical and Diagnostic Sciences (DISC) Pathology Unit University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kanitakis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ed. Herriot Hospital Group Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Parodi","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DISSAL) University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Rongioletti","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Health Sciences (DISSAL) University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"},{"name":"Department of Surgical and Diagnostic Sciences (DISC) Pathology Unit University of Genoa and IRCCS San Martino\u2010IST University Hospital Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05292.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)70075-1"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12577"},{"key":"e_1_2_5_5_1","first-page":"797","article-title":"Lupus erythematosus tumidus: clinical, histopathological and serological aspects and therapy response of 21 patients","volume":"20","author":"Cozzani E","year":"2010","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1033"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.435"},{"key":"e_1_2_5_8_1","volume-title":"Dermatology","author":"Rongioletti F","year":"2008"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1974.tb15865.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2011.04.005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1982.tb00896.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660280125039"},{"key":"e_1_2_5_13_1","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1001\/archderm.1979.04010110046025","article-title":"Reticular erythematous mucinosis syndrome. 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