{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:25:28Z","timestamp":1792689928010,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T00:00:00Z","timestamp":1411948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n A subset of patients with chronic spontaneous urticaria (\n CSU<\/jats:styled-content>\n ) experience disease exacerbations after receiving non\u2010steroidal anti\u2010inflammatory drugs (\n NSAID<\/jats:styled-content>\n s). This condition has been designated as Aspirin\u2010Exacerbated Cutaneous Disease (\n AECD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n The purpose of this study was twofold: (i) Investigate the demographic and clinical features of patients affected by\n AECD<\/jats:styled-content>\n ; (ii) To compare patients with\n AECD<\/jats:styled-content>\n and\n NSAID<\/jats:styled-content>\n \u2010tolerant\n CSU<\/jats:styled-content>\n patients for those characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Patients with\n AECD<\/jats:styled-content>\n and a group of unselected\n CSU<\/jats:styled-content>\n patients tolerant to\n NSAID<\/jats:styled-content>\n s were studied. Demographic and clinical data were obtained by direct questioning and physical examination. Laboratory investigations and allergen skin prick tests were performed only in selected patients, as guided by the medical history.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 423\n CSU<\/jats:styled-content>\n patients admitted in the clinics, 52 (12.2%) had\n AECD<\/jats:styled-content>\n . Compared with\n NSAID<\/jats:styled-content>\n \u2010tolerant\n CSU<\/jats:styled-content>\n patients,\n AECD<\/jats:styled-content>\n patients had significantly longer disease duration (57.7\u00a0\u00b1\u00a0118.4 vs. 24.4\u00a0\u00b1\u00a036.6\u00a0months,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05), higher prevalence of angio\u2010oedema (72.7 vs. 30.9%,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) and atopy (83.8% vs. 58.4%,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05) and more frequent involvement of the face and upper respiratory tract (54.5% vs. 29.6%,\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n AECD<\/jats:styled-content>\n is a distinct phenotype that should be considered for inclusion as a separate subtype of chronic spontaneous urticaria.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12658","type":"journal-article","created":{"date-parts":[[2014,9,29]],"date-time":"2014-09-29T04:03:23Z","timestamp":1411963403000},"page":"698-701","source":"Crossref","is-referenced-by-count":46,"title":["Aspirin\u2010exacerbated cutaneous disease (\n AECD<\/scp>\n ) is a distinct subphenotype of chronic spontaneous urticaria"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"S\u00e1nchez\u2010Borges","sequence":"first","affiliation":[{"name":"Department of Allergy and Clinical Immunology Cl\u00ednica El Avila Caracas Venezuela"},{"name":"Department of Allergy and Clinical Immunology Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Caballero\u2010Fonseca","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Capriles\u2010Hulett","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gonz\u00e1lez\u2010Aveledo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centro M\u00e9dico de Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12313"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5574.262"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02557.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.03.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2012.10.004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/B978-0-323-08593-9.00081-4","volume-title":"Middleton's Allergy. 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