{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T09:42:03Z","timestamp":1793353323613,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T00:00:00Z","timestamp":1410134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) recurrences, especially in the facial region, represent a complex cosmetic problem. To date the possibility of predicting recurrence is supported solely by the histologic subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the relationship between <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> histologic subtypes linked to high and low risk of recurrence and the presence of hyperechoic spots on sonography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of the pre\u2010surgical ultrasound examinations of primary <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> tumours with visualization and counting of intra\u2010tumoural hyperechoic spots. The data were then correlated with the corresponding histologic subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty one patients with histologically proven <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> were included in the study. Hyperechoic spots were detected in all cases and there was a positive, statistically significant association between hyperechoic spots count and high recurrence risk histologic subtypes. Higher hyperechoic spots count was found in the recurrence\u2010prone micronodular, sclerosing variant and morpheiform <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> subtypes. Low risk and high risk of recurrence showed a significant difference on the mean hyperechoic spots count of 5.5 (range: 3\u201325) and 8 (4\u201381). A cut\u2010off point \u22657 hyperechoic spots presented a sensitivity of 79% and specificity of 53% for predicting the high risk of recurrence subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence and count of hyperechoic spots within <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> lesions may help predicting the high risk of recurrence histologic subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12660","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T15:32:49Z","timestamp":1410190369000},"page":"702-707","source":"Crossref","is-referenced-by-count":85,"title":["Ultrasound as predictor of histologic subtypes linked to recurrence in basal cell carcinoma of the skin"],"prefix":"10.1111","volume":"29","author":[{"given":"X.","family":"Wortsman","sequence":"first","affiliation":[{"name":"Departments of Radiology and Dermatology IDIEP, Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues Clinica Servet Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinico U. Chile Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Castro","sequence":"additional","affiliation":[{"name":"Office for Clinical Research Support Hospital Clinico U. Chile Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Clinica Davila and Hospital Clinico U. Chile Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Bobadilla","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Barros Luco Trudeau Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Sazunic","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermopathology Section Histodiagnostico Malaga Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Zemelman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinico U. Chile Faculty of Medicine University of Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wortsman","sequence":"additional","affiliation":[{"name":"Department of Medicine Southern Illinois University School of Medicine Springfield Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"S365","article-title":"Emerging trends and treatment approaches in nonmelanoma skin cancer: a Canadian perspective","volume":"15","author":"Kuzel P","year":"2011","journal-title":"J Cutan Med Surg"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01340.x"},{"key":"e_1_2_6_5_1","first-page":"67","article-title":"Recurrent basal cell carcinoma: a clinicopathological study and evaluation of histomorphological findings in primary and recurrent lesions","volume":"20","author":"Barto\u0161 V","year":"2011","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"e_1_2_6_6_1","first-page":"262","article-title":"Comparision of histological types of primary and subsequent relapsing basal cell carcinomas of the skin","volume":"25","author":"Bartos V","year":"2012","journal-title":"Klin Onkol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800512"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1993.tb00230.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0236"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00535.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2013.32.4.567"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2008.0026"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33256.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70344-H"},{"key":"e_1_2_6_16_1","first-page":"340","article-title":"Can High\u2010Frequency Skin Ultrasound Be Used for the Diagnosis and Management of Basal Cell Carcinoma?","volume":"26","author":"Hern\u00e1ndez C","year":"2013","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1321-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00619.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1231"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.8.1041"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12660","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:23:08Z","timestamp":1695471788000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,8]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jdv.12660"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12660","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,8]]}}}