{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:40:12Z","timestamp":1773088812632,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) is an acquired autoimmune disease, with typical histology and immune pathological findings, which might be associated with drug therapy. The list of responsible drugs increases every year, but a current literature revision do not include the mammalian target of rapamycin (<jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content>) inhibitors. By converse, bullous pemghigoid cases have been described in renal transplant recipients and associated with the allogenic graft itself, causing a cross reaction against the skin, or unbalancing the immune response, through a chronic cell\u2010mediated suppression, non\u2010specifically favouring the autoantibody production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Object and results<\/jats:title><jats:p>Two cases of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> occurred, respectively, 10\u00a0days to 2\u00a0months after the addition to their current regimen of everolimus in a 35\u2010year\u2010old woman and sirolimus in a 65\u2010year\u2010old man. The graft functionality was within normal range. General corticosteroids therapy resistance, immediate improvement after drug discontinuation (dechallenge) and relapse after re\u2010exposure (rechallenge) were striking criteria supporting a causative role of the drugs, grouped in the <jats:styled-content style=\"fixed-case\">mTOR<\/jats:styled-content> inhibitors class.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The diagnosis of drug\u2010induced events is crucial for early management, and particularly bullous eruptions affect patients' health and quality of life. Additional research is necessary to confirm the m\u2010<jats:styled-content style=\"fixed-case\">TOR<\/jats:styled-content> inhibitors association, which exploit the possible mechanisms and eventually point out preventive measures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12662","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T13:41:06Z","timestamp":1409319666000},"page":"1626-1630","source":"Crossref","is-referenced-by-count":15,"title":["Bullous pemphigoid induced by m\u2010<scp>TOR<\/scp> inhibitors in renal transplant recipients"],"prefix":"10.1111","volume":"29","author":[{"given":"L.","family":"Atzori","sequence":"first","affiliation":[{"name":"Dermatology Clinic Department of Medical Science \u201cM.Aresu\u201d University of Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Dermatology AOU of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zucca","sequence":"additional","affiliation":[{"name":"Department of Dermatology AOU of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pau","sequence":"additional","affiliation":[{"name":"Department of Dermatology AOU of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2010.01140.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00858.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.141"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329902"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1684\/ejd.2012.1673","article-title":"Bullous pemphigoid in a transplant recipient: is this a sign of allograft rejection?","volume":"22","author":"De Simone C","year":"2012","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200910030-00007"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181c27f99"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02145.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.05.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.03.005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.376"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2515\/therapie\/2009041"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-32-83"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12662","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12662","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:23:20Z","timestamp":1695554600000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,29]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/jdv.12662"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12662","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,29]]}}}