{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:53:44Z","timestamp":1732035224134},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Following the recent elucidation of its pathogenic mechanisms involving reactive oxygen species, use of vitamins, folic acid and antioxidants as adjuvant therapy has been suggested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the long\u2010term outcome of childhood facial vitiligo who were treated with nutritional education, vitamin E (\u03b1\u2010tocopherol 100\u2013400\u00a0IU\/day), folic acid (1\u20132\u00a0mg\/day) and multivitamin intake and antioxidant cosmetics as the mainstay of treatment as well as the conventional therapies including oral, topical and\/or intralesional corticosteroid, topical macrolactam, Excimer laser and epidermal graft.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical data and photographs of 111 paediatric facial vitiligo patients who had been followed up for longer than 1\u00a0year from March 1, 2003 to June 30, 2013 were extracted from data warehouse of electric medical records. Photographic evaluation and final visual outcome assessment was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>By investigator's assessment, 9% of patients demonstrated no improvement regardless of treatment modality, whereas 91% showed improvement of lesions. Among the latter, 33.3% resulted in &gt;75% improvement; 18% in 50%\u201375% improvement; 26.1% in 25%\u201350% improvement; and 13.5% in &lt;25% improvement. In the final visual outcome assessment, \u2018Looking excellent\u2019 was seen in 42.3%; \u2018looking very good\u2019 in 30.6%; \u2018looking good\u2019 in 17.1%; \u2018looking fair\u2019 in 9.0%; and \u2018looking bad\u2019 in 0.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although childhood facial vitiligo is quite refractory to treatment, the long\u2010term outcome of this condition is not dismal with conventional vitiligo therapy along with basic nutritional therapeutic regimen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12666","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T13:46:19Z","timestamp":1409319979000},"page":"713-718","source":"Crossref","is-referenced-by-count":3,"title":["Childhood facial vitiligo: how intractable is it?"],"prefix":"10.1111","volume":"29","author":[{"given":"S. A.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology SMG\u2010SNU Boramae Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. H.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. T.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. I.","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. C.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeong\u2010gi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01369.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11197.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04142.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1999.40.3.195"},{"key":"e_1_2_5_7_1","first-page":"39","article-title":"Folic acid and vitamin B12 in vitiligo: a nutritional approach","volume":"50","author":"Montes LF","year":"1992","journal-title":"Cutis"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2012.1884"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12103"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.108040"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2000.01749.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2005.10.001"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.90943"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0964-4"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.39577"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2003.tb00356.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-006-0680-2"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2010.22.3.279"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.3.12114"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270009335769"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.2165\/11630540-000000000-00000"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02514.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410021565"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2340\/000155555577460462","article-title":"Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure","volume":"77","author":"Juhlin L","year":"1997","journal-title":"Acta Derm Venereol"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12666","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:23:06Z","timestamp":1695471786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,29]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1111\/jdv.12666"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12666","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,29]]}}}