{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:09:06Z","timestamp":1777122546363,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous melanomas are diagnosed worldwide in 231\u00a0130 patients per year. The sensitivity and specificity of melanoma diagnosis expresses the need for an additional diagnostic method. Optical coherence tomography (<jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>) has shown that it allows morphological (qualitative) description of image features and quantitative analysis of pathology related light scattering by means of the attenuation coefficient (\u03bc<jats:sub>oct<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We hypothesize that <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images of nevi will differ qualitatively and quantitatively from melanomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty lesions from 33 consecutive patients were imaged with <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>. After data acquisition, excision was performed. Epidermal layer thickness was measured and values of \u03bc<jats:sub>oct<\/jats:sub> were extracted from 200 <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images of pigmented lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Morphologically, absence of the lower border of the lesion was characteristic for melanoma (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). Also, the \u03bc<jats:sub>oct<\/jats:sub> was different between benign and malignant lesions (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.02). There were no differences in epidermal layer thickness of benign lesions and melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although this preliminary study comprised a small number of patients, quantitative analysis of <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> images in pigmented skin lesions give valuable additional information about lesions characteristics. When using the attenuation coefficient, it might be possible to distinguish between benign lesions and melanomas.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12673","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T13:46:35Z","timestamp":1409319995000},"page":"738-744","source":"Crossref","is-referenced-by-count":18,"title":["Functional optical coherence tomography of pigmented lesions"],"prefix":"10.1111","volume":"29","author":[{"given":"R.","family":"Wessels","sequence":"first","affiliation":[{"name":"Department of Surgery NKI\u2010AvL Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.M.","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering &amp; Physics AMC\u2010UvA Amsterdam the Netherlands"},{"name":"Department of Urology AMC\u2010UvA Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.N.","family":"Relyveld","sequence":"additional","affiliation":[{"name":"Department of Dermatology NKI\u2010AvL Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.J.","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering &amp; Physics AMC\u2010UvA Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.D.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Biometrics NKI\u2010AvL Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Pathology NKI\u2010AvL Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.G.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering &amp; Physics AMC\u2010UvA Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.M.","family":"Ruers","sequence":"additional","affiliation":[{"name":"Department of Surgery NKI\u2010AvL Amsterdam the Netherlands"},{"name":"Nanobiophysics Group MIRA Institute University Twente Enschede the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,29]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"International Agency for Research on Cancer.GLOBOCAN 2012 Estimated Cancer Incidence Mortality and Prevalence worldwide in 2012. 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