{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:41:24Z","timestamp":1759815684831,"version":"3.37.3"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["APQ1 2010\/2","E-26\/110.322\/2011"],"award-info":[{"award-number":["APQ1 2010\/2","E-26\/110.322\/2011"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Geographic tongue (<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>) is the most frequent oral lesion in psoriatic patients (<jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>), and genetic involvement in these conditions has been described. The association of psoriasis with <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> is still not clear, and the study of human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) may help clarify this relation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alleles with psoriasis vulgaris and <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010eight Brazilian <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content>, 29 <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> patients and 125 healthy controls individuals were selected. Information on demographic and clinical characteristics was collected. All patients underwent an oral examination and blood collection for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> typing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A did not show significant differences in frequencies among the groups. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*57 allele was more frequently found in <jats:styled-content style=\"fixed-case\">PP<\/jats:styled-content> and was not found in <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*58 allele was more frequently found in <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C*06 and \u2010C*18 alleles were associated with psoriasis. No significant differences in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DQB<\/jats:styled-content>1 were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*58 was associated with <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*57 was possibly associated with psoriasis. This suggested that some <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> cases may represent true oral psoriasis and some may represent only <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>. Therefore, it is necessary to make this distinction and increase our sample size to improve the correct diagnosis and treatment of these conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12691","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T14:30:56Z","timestamp":1409322656000},"page":"865-874","source":"Crossref","is-referenced-by-count":14,"title":["A possible relationship of human leucocyte antigens with psoriasis vulgaris and geographic tongue"],"prefix":"10.1111","volume":"29","author":[{"given":"B.L.S.","family":"Picciani","sequence":"first","affiliation":[{"name":"Department of Pathology Universidade Federal Fluminense Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Sector of Dermatology Medical Clinic Department Universidade Federal do Rio de Janeiro Rio de Janeiro 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