{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:14:37Z","timestamp":1757704477706},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T00:00:00Z","timestamp":1409702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Molluscum contagiosum (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) is caused by a <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> virus of the poxvirus group. It is common in children, and is also found in sexually active adults and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010seropositive patients. Cellular immunity is essential to controlling MC virus infection. We report the first observation of a patient with stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> Sezary syndrome, who presented multiple molluscum contagiosum, spread and surrounded by a pale halo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A woman aged 70 presented with aggravation of Sezary syndrome diagnosed in 2009 and treated with topical corticosteroids. The examination showed a generalized pruritic exanthem and multiple flesh\u2010coloured papules from 1 to 3\u00a0mm, spread over the entire skin surface and surrounded by a white halo. Histological examination of a lesion showed the presence of infected cells with intracytoplasmic inclusions infected in an acanthotic epidermis, surrounded by a melaninopenic hypomelanosis with a normal melanocyte density. There was no inflammatory character. The diagnosis of multiple molluscum contagiosum was given, the application of clobetasol propionate was suspended and treatment with chlorambucil 4\u00a0mg\/day and prednisone 0.5\u00a0mg\/kg\/day was started. The evolution of the rash and pruritus was rapidly favourable. After 3\u00a0months, the rash and pruritus had regressed. There was no molluscum contagiosum or clear halo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report the original observation of a patient with stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> Sezary syndrome, who presented multiple molluscum contagiosum, spread and surrounded by a pale halo, without inflammation, eczema or disappearance of melanocytes. This halo could be due to the secretion of a protein by molluscum contagiosum inhibiting inflammation around this <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>. To our knowledge, this phenomenon reported in a patient with severe atopic dermatitis associated with Sezary syndrome has not previously been described.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12694","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T10:04:14Z","timestamp":1409738654000},"page":"1837-1839","source":"Crossref","is-referenced-by-count":6,"title":["Molluscum contagiosum surrounded by a white halo and Sezary syndrome"],"prefix":"10.1111","volume":"29","author":[{"given":"C.","family":"Le Treut","sequence":"first","affiliation":[{"name":"Service de dermatologie b\u00e2timent des sp\u00e9cialit\u00e9s m\u00e9dicales CHU de Nancy all\u00e9e du Morvan Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Granel\u2010Brocard","sequence":"additional","affiliation":[{"name":"Service de dermatologie b\u00e2timent des sp\u00e9cialit\u00e9s m\u00e9dicales CHU de Nancy all\u00e9e du 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