{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T22:42:32Z","timestamp":1774737752344,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T00:00:00Z","timestamp":1409270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Increased adrenocortical production appears to be associated with acne and hirsutism in acne and polycystic ovary syndrome (PCOS). However, the aetiological role of androgens in the pathogenesis of acne per se is far from being clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to evaluate adrenocortical function in women with post\u2010adolescent severe acne in comparison with patients with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and healthy women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 32 women with post\u2010adolescent severe acne, 32 women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and 32 age and body mass index (BMI)\u2010matched healthy controls (age 17\u201334\u00a0years, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>: 20.8\u00a0\u00b1\u00a01.9\u00a0kg\/m\u00b2). Women with acne did not have hirsutism or ovulatory dysfunction whereas all <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients had androgen excess and ovulatory dysfunction. Measurements included basal testosterone (T), sex hormone\u2010binding globulin (SHBG) and dehydroepiandrosterone sulphate (DHEAS) levels and serum 17\u2010hydroxyprogesterone (17\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content>), androstenedione (A4), <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content> and cortisol levels in response to corticotropin (ACTH) stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T, free androgen index, <jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content> levels, basal and <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> (area under the curve) values for A4 were significantly higher in <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> than women with acne and controls (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05 for all), whereas three groups did not differ for basal or <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> values of <jats:styled-content style=\"fixed-case\">DHEA<\/jats:styled-content> and cortisol. Women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and those with severe acne had significantly and similarly higher <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content> values of 17\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> compared to controls (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with isolated post\u2010adolescent severe acne do not have increased levels of adrenal androgens basally or in response to <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>. However, these women have similar secretion pattern of 17\u2010<jats:styled-content style=\"fixed-case\">OHP<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> patients suggesting increased enzymatic activity in this pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12696","type":"journal-article","created":{"date-parts":[[2014,8,29]],"date-time":"2014-08-29T13:47:26Z","timestamp":1409320046000},"page":"875-880","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of adrenocortical steroidogenesis in women with post\u2010adolescent severe acne and polycystic ovary syndrome"],"prefix":"10.1111","volume":"29","author":[{"given":"N.","family":"Cinar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Endocrinology and Metabolism Hacettepe University School of Medicine Hacettepe Ankara 06100 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