{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:39:07Z","timestamp":1790653147340,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T00:00:00Z","timestamp":1410739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Narrow\u2010band ultraviolet B (NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>) is an effective and safe treatment for vitiligo. Calcipotriol, a synthetic analogue of 1,25 dihydroxyvitamin D3 may regulate melanin synthesis. Several clinical studies have been conducted but the synergistic effect of addition of calcipotriol toNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>in the treatment of vitiligo is still debatable.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To compare the efficacy and safety of topical calcipotriol (0.005%) in combination withNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>vs.NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>alone in generalized vitiligo.<\/jats:p><\/jats:sec>Methods<\/jats:title>A prospective right\u2013left comparative study including 27 patients of vitiligo was conducted for 24\u00a0weeks. On one side, calcipotriol was applied twice a day.NB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>was administered thrice a week. Response to treatment was assessed using change in Lund and Browder (L&B) score for percentage reduction in body surface area, investigator's global assessment (IGA<\/jats:styled-content>) and patient's global assessment (PGA<\/jats:styled-content>) scores. Treatment related side effects were noted.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean percentage reduction in L&B score at 24\u00a0weeks was 51.4% onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>and 49% onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>plus calcipotriol side (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.557), meanIGA<\/jats:styled-content>score onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>was 2.7\u00a0\u00b1\u00a00.5 and onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>plus calcipotriol was 2.6\u00a0\u00b1\u00a00.4 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.821) and meanPGA<\/jats:styled-content>score onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>side was 5.6\u00a0\u00b1\u00a03.4 and onNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>plus calcipotriol side was 5.8\u00a0\u00b1\u00a03.2 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.706). Perifollicular repigmentation that matched with the surrounding normal skin colour was seen in majority of patients on both treatment sides. Calcipotriol produced mild local adverse effects.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Addition of calcipotriol toNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>probably does not enhance the efficacy of treatment including extent of repigmentation and time to initial repigmentation. Larger, randomized placebo\u2010controlled trials are required to determine whether addition of calcipotriol has any utility when administered withNB<\/jats:styled-content>\u2010UVB<\/jats:styled-content>in the treatment of vitiligo.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12726","type":"journal-article","created":{"date-parts":[[2014,9,15]],"date-time":"2014-09-15T11:37:22Z","timestamp":1410781042000},"page":"925-932","source":"Crossref","is-referenced-by-count":39,"title":["Comparison of efficacy and safety profile of topical calcipotriol ointment in combination withNB<\/scp>\u2010UVB<\/scp>vs.NB<\/scp>\u2010UVB<\/scp>alone in the treatment of vitiligo: a 24\u2010week prospective right\u2013left comparative clinical trial"],"prefix":"10.1111","volume":"29","author":[{"given":"G.","family":"Khullar","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.J.","family":"Kanwar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Employees' State Insurance Corporation Medical College and Hospital NH\u20103 NIT Faridabad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Parsad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Postgraduate Institute of Medical Education and Research Chandigarh 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