{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T01:49:14Z","timestamp":1793411354653,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Porokeratotic adnexal ostial nevus (<jats:styled-content style=\"fixed-case\">PAON<\/jats:styled-content>) is a term that encompass porokeratotic eccrine ostial and dermal duct naevus and porokeratotic eccrine and hair follicle naevus. <jats:styled-content style=\"fixed-case\">PAON<\/jats:styled-content> is a rare adnexal hamartoma characterized by the presence of a cornoid lamella exclusively overlying eccrine acrosyringia or over both, eccrine acrosyringia and hair follicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Most of the articles on <jats:styled-content style=\"fixed-case\">PAON<\/jats:styled-content> report its clinical or histopathological characteristics but literature review offer scarce data on the evolution or treatment. We have reviewed it.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>We report an 8\u2010year\u2010old boy with presence of bilateral asymtomatic verrucous lesions mostly in left side of the body without other added abnormalities through the twelve\u2010year follow\u2010up. As our case presented cornoid lamella overlying eccrine acrosyringia and hair follicles we diagnosed <jats:styled-content style=\"fixed-case\">PEHFN<\/jats:styled-content>. He received treatment with <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> ablation in 2004 and in 2012 with marked improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Review of the previous reported cases of <jats:styled-content style=\"fixed-case\">PAON<\/jats:styled-content> show that it is mostly unilateral and that some patients have coexisting problems like seizures, left hemiparesis, scoliosis, deafness, developmental delay, palmoplantar keratoderma, psoriasis, hyperthyroidism, polinerupathy, breast hipoplasia and <jats:styled-content style=\"fixed-case\">KID<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PAON<\/jats:styled-content> responded with tazaroten gel, dithranol short\u2010contact treatment and topical photodynamic therapy but laser treatments appear to be more efficient in most patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12732","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T07:02:03Z","timestamp":1411714923000},"page":"2032-2037","source":"Crossref","is-referenced-by-count":21,"title":["Porokeratotic adnexal ostial naevus: review on the entity and therapeutic approach"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Llamas\u2010Velasco","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Infanta Cristina Parla Madrid Spain"},{"name":"Kempf und Pfaltz Histologische Diagnostik Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Hilty","sequence":"additional","affiliation":[{"name":"Dermatology Practice Dermapoint Vaduz Liechtenstein"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Kempf","sequence":"additional","affiliation":[{"name":"Kempf und Pfaltz Histologische Diagnostik Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,26]]},"reference":[{"issue":"61","key":"e_1_2_4_2_1","first-page":"e1","article-title":"Widespread porokeratotic adnexal ostial nevus: clinical features and proposal of a new name unifying porokeratotic eccrine ostial and dermal duct nevus and porokeratotic eccrine and hair follicle nevus","volume":"2009","author":"Goddard DS","journal-title":"J Am Acad Dermatol"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb05653.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1980.tb07268.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80129-1"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03210.x"},{"key":"e_1_2_4_7_1","first-page":"496","article-title":"Bowen's disease on porokeratotic eccrine ostial and dermal duct nevus","volume":"33","author":"Coras B","year":"2007","journal-title":"Dermatol Surg"},{"key":"e_1_2_4_8_1","article-title":"Hybrid eccrine gland and hair follicle hamartoma: a new entity of adnexal nevus","author":"Luo DQ","year":"2013","journal-title":"Am J Dermatopathol"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02186.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246230"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01019.x"},{"key":"e_1_2_4_12_1","first-page":"218","article-title":"Late\u2010onset porokeratotic eccrine ostial and dermal duct nevus associated with sensory polyneuropathy and hyperthyroidism","volume":"11","author":"Rasi A","year":"2008","journal-title":"Arch Iran Med"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70110-9"},{"key":"e_1_2_4_14_1","first-page":"495","article-title":"Porokeratotic eccrine ostial and dermal duct nevus: a case of systematized involvement","volume":"46","author":"Cobb MW","year":"1990","journal-title":"Cutis"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00367.x"},{"issue":"1220","key":"e_1_2_4_16_1","first-page":"23","article-title":"Puzzling palmar and plantar papules. 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