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The condition is considered to be characterized by a triad of symptoms (conjunctivitis, arthritis and urethritis) although a constellation of other manifestations may also be present. ReA is characterized by psoriasiform dermatological manifestations that may resemble those of pustular psoriasis and, similar to guttate psoriasis, is a post\u2010infectious entity. Also, the articular manifestations of the disorder are similar to those of psoriatic arthritis and both conditions show a correlation with <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27. These facts have led several authors to suggest that there is a connection between ReA and psoriasis, listing ReA among the disorders related to psoriasis. However, the pathogenetic mechanism behind the condition is complex and poorly understood. Bacterial antigenicity, the type of host response (i.e. Th1\/Th2 imbalance) and various genetic factors (i.e. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B27 etc.) play an important role in the development of the disorder. It is unknown whether all the aforementioned factors are part of a mechanism that could be similar to, or share basic aspects with known psoriasis pathogenesis mechanisms.<\/jats:p>","DOI":"10.1111\/jdv.12741","type":"journal-article","created":{"date-parts":[[2014,9,8]],"date-time":"2014-09-08T15:33:12Z","timestamp":1410190392000},"page":"415-424","source":"Crossref","is-referenced-by-count":72,"title":["Reactive Arthritis"],"prefix":"10.1111","volume":"29","author":[{"given":"P.G.","family":"Stavropoulos","sequence":"first","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u2018Andreas Syggros\u2019 Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Soura","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u2018Andreas Syggros\u2019 Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kanelleas","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u2018Andreas Syggros\u2019 Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katsambas","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u2018Andreas Syggros\u2019 Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"1st Department of Dermatology\/University Clinic \u2018Andreas Syggros\u2019 Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"101","article-title":"Reiter's syndrome and reactive arthritis","volume":"100","author":"Parker CT","year":"2000","journal-title":"J Am Osteopath"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1135542"},{"key":"e_1_2_7_4_1","first-page":"2030","article-title":"Contribution a l'etude d'une epidemie de dysenterie dans le somme","volume":"40","author":"Fiessinger M","year":"1916","journal-title":"Bull Mem Soc Med*\/ Hop Paris"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.bor.0000163447.44037.c4"},{"key":"e_1_2_7_6_1","first-page":"2185","article-title":"On the difficulties of establishing a consensus on the definition of and diagnostic investigations of reactive arthritis. 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