{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:21:14Z","timestamp":1781536874618,"version":"3.54.5"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Folliculotropic mycosis fungoides (FMF) represents a variant of <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> characterized by hair follicle invasion of mature, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4\u2010positive small lymphoid cells with cerebriform nuclei. The disease displays resistance to standard treatment modalities and has an unfavourable course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Clinical analysis of 17 patients with <jats:styled-content style=\"fixed-case\">FMF<\/jats:styled-content> collected between 2005 and 2012, investigation of tumour cells and involved hair follicle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Re\u2010evaluation of clinical data, wide panel immunohistochemistry investigation on paraffin\u2010embedded biopsy material, T\u2010cell receptor gene rearrangement analysis of the samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Male and older age group predominance, frequent head\u2013neck involvement, acneiform lesions, keratotic plugs, cysts, nodules, follicular papules, alopecia and classic mycosis fungoides\u2010like plaques represented the main clinical characteristics. Treatment response showed a wide range from transient complete response to therapy resistance and death due to the disease. The pathological alterations: folliculotropism, mild epidermotropism, follicular plugging, mucinous degeneration of hair follicle, basaloid hyperplasia, syringotropism were similar to those observed previously. The first case of a <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8\u2010positive folliculotropic mycosis fungoides \u2013 with unusual clinical presentation \u2013 is reported here. Nestin overexpression of mesenchymal cells of the isthmic and suprabulbar regions of hair follicle and the reappearance of dermal nestin\u2010expressing cells were observed in association with immature dendritic cell hyperplasia. Altered <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>19 expression was detected suggesting a potential role of follicular keratinocytes in the disease process. It was found that a proportion of neoplastic T cells constantly express programmed death\u20101 receptor in our patients contrary to classic mycosis fungoides.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The spectrum of the clinical manifestation and the course of folliculotropic mycosis fungoides are broad and differ from classic mycosis fungoides. Folliculotropic neoplastic T\u2010cell proliferation is associated with activation of inflammatory reactive T\u2010 and B\u2010lymphoid cells, mesenchymal cells and changes in the hair follicle.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12743","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T12:07:08Z","timestamp":1416312428000},"page":"964-972","source":"Crossref","is-referenced-by-count":37,"title":["Folliculotropic mycosis fungoides: clinicopathological analysis of 17 patients"],"prefix":"10.1111","volume":"29","author":[{"given":"M.","family":"Marschalk\u00f3","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Dermatooncology Semmelweis University Faculty of Medicine Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Er\u0151s","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Dermatooncology Semmelweis University Faculty of 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