{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:30:48Z","timestamp":1782228648955,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Management of oral lichen planus (OLP) is challenging and therapeutic options are limited. The use of topical tacrolimus has shown promising results. We reviewed our daily life experience with topical tacrolimus in OLP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective unicentre study included all 21 patients with OLP, which were evaluated over a 53\u2010month period and treated with topical tacrolimus. Patients were initially given a topical preparation of 0.1% tacrolimus twice daily. The response to treatment was assessed using a 4\u2010point scale at month 2 and 6: complete response of affected area (CR), major remission (&gt;50%, MR), partial remission (25\u201350%, PR) and either no response (&lt;25%) or worsening. The pain score was also assessed using a 3\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four of 21 patients (19%) showed a CR at month 2, whereas at month 6, 7 (33%) had a CR. For patients who reported MR (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and PR (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) at month 2, the therapy was continued. Of those, at 6\u00a0months, three patients showed a CR, while four maintained a PR. The pain score improved during treatment. After 2\u00a0months of therapy, eight of 10 patients with an initial high pain score achieved a significant improvement. In patients starting with moderate pain an improvement was observed in one of seven patients. Overall, for three patients there was a complete loss of pain, while in nine there was a reduction. Except for transitory burning sensation and altered taste sensation, no relevant side\u2010effects were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective analysis confirms that topical tacrolimus is a valuable therapeutic option in severe or treatment\u2010resistant OLP. Our findings in daily practice suggested nevertheless that the efficacy of topical tacrolimus is overestimated with regard to both complete response and pain reduction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12758","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T04:56:55Z","timestamp":1413176215000},"page":"1107-1113","source":"Crossref","is-referenced-by-count":19,"title":["Efficacy of topical tacrolimus for oral lichen planus: real\u2010life experience in a retrospective cohort of patients with a review of the literature"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Ribero","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital\u2010Inselspital Bern University of Bern Bern Switzerland"},{"name":"Section of Dermatology Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stieger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital\u2010Inselspital Bern University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Section of Dermatology Department of Medical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hongang","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital\u2010Inselspital Bern University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Stomatology School of Dental Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Naldi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Azienda Ospedaliera Papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Borradori","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital\u2010Inselspital Bern University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_5_3_1","first-page":"917","article-title":"Oral lichen planus treated with tacrolimus 0.1%","volume":"6","author":"Resende JP","year":"2013","journal-title":"Int J Clin Exp Med"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0070"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.07.029"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2000.00607.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2007.07.199"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10821.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.11.1427"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01516.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2008.00203.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410030720"},{"key":"e_1_2_5_13_1","first-page":"76","article-title":"Comparison of therapeutic effect of low\u2010dose low\u2010molecular\u2010weight heparin (enoxaparin) vs. oral prednisone in treatment of patients with lichen planus; A clinical trial. 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