{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:18:20Z","timestamp":1790068700916,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Idiopathic guttate hypomelanosis (<jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>) is a common pigmentary disorder affecting a large number of individuals. Many patients seek medical attention due to aesthetic concern. However, no standard treatment is available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy and side\u2010effects of non\u2010ablative fractional photothermolysis (FP) as a treatment of <jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A total of 120 lesions from 30 patients with <jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content> were treated. In each patient, two lesions on the extremities were assigned to treatment group, while lesions from the other side served as control. The treatment was delivered by fractional 1550\u2010nm ytterbium\/erbium fibre laser for four times at 4\u2010week intervals. Lesional skin colour was measured by colourimetry. Digital photographs and dermoscopic digital photographs were taken at weeks 0, 4, 8, 12 and 16. In addition, patient satisfaction score and side\u2010effects were recorded. All clinical photographs were evaluated by three experienced dermatologists to determine clinical improvement using a quartile grading scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Colourimetry of the treatment side showed normalization of skin colour at each visit and was statistically significant when compared with control after two treatments (week 8) and continued to decrease until 4\u00a0weeks' follow\u2010up (week 16) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.047, 0.016 and 0.06 respectively). Physicians' improvement grading score showed that 83.34% of the lesions in treatment group vs. 18.34% in the control group showed some improvement. The difference was statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Common side\u2010effects were erythema and oedema in treatment area, which were mild and transient. No post\u2010inflammatory hyperpigmentation was observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Non\u2010ablative FP appears to be an effective way to treat <jats:styled-content style=\"fixed-case\">IGH<\/jats:styled-content>. The improvements are documented by both objective and subjective measurements.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12763","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T10:28:41Z","timestamp":1412936921000},"page":"2238-2242","source":"Crossref","is-referenced-by-count":17,"title":["Non\u2010ablative fractional photothermolysis in treatment of idiopathic guttate hypomelanosis"],"prefix":"10.1111","volume":"29","author":[{"given":"P.","family":"Rerknimitr","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Dermatology Unit Department of Medicine King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Chitvanich","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Dermatology Unit Department of Medicine King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Pongprutthipan","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Panchaprateep","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"Dermatology Unit Department of Medicine King Chulalongkorn Memorial Hospital Thai Red Cross Society Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Asawanonda","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04743.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04209.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70273-K"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00701.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.1999.99186-8.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750010724"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04462.x"},{"key":"e_1_2_5_9_1","first-page":"238","article-title":"Pimecrolimus for idiopathic guttate hypomelanosis","volume":"9","author":"Asawanonda 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