{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:42:28Z","timestamp":1792078948535,"version":"4.4.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T00:00:00Z","timestamp":1412899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009457","name":"Region Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009457","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Danish Psoriasis Research Foundation"},{"name":"Axel Muusfeldt Foundation"},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Psoriasis is a common disease and is associated with cardiovascular diseases. Systemic anti\u2010inflammatory drugs may reduce risk of cardiovascular events. We therefore examined the rate of cardiovascular events, i.e. cardiovascular death, myocardial infarction and stroke, in patients with severe psoriasis treated with systemic anti\u2010inflammatory drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Individual\u2010level linkage of administrative registries was used to perform a longitudinal nationwide cohort study\n                      <jats:bold>.<\/jats:bold>\n                      Time\u2010dependent multivariable adjusted Cox regression was used to estimate hazard ratios (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      s) with 95% confidence intervals (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      s) of cardiovascular events associated with use of biological drugs, methotrexate, cyclosporine, retinoids and other antipsoriatic therapies, including topical treatments, phototherapy and climate therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 6902 patients (9662 treatment exposures) with a maximum follow\u2010up of 5\u00a0years were included. Incidence rates per 1000 patients\u2010years for cardiovascular events were 4.16, 6.28, 6.08, 18.95 and 14.63 for biological drugs, methotrexate, cyclosporine, retinoid and other therapies respectively. Relative to other therapies, methotrexate (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.53;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.34\u20130.83) was associated with reduced risk of the composite endpoint and a comparable but non\u2010significant protective effect was observed with biological drugs (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.58;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.30\u20131.10), whereas no protective effect was apparent with cyclosporine (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.06;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.26\u20134.27) and retinoids (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.80;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.03\u20132.96). Tumour necrosis factor inhibitors (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      0.46;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.22\u20130.98) were linked to reduced event rates, whereas the interleukin\u201012\/23 inhibitor ustekinumab (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      1.52;\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.47\u20134.94) was not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Systemic anti\u2010inflammatory treatment with methotrexate was associated with significantly lower rates of cardiovascular events during long\u2010term follow\u2010up compared to patients treated with other antipsoriatic therapies. The treatment strategy in patients with severe psoriasis may have an impact on cardiovascular outcomes and randomized trials to evaluate the cardiovascular safety and efficacy of systemic antipsoriatic therapies are called for.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.12768","type":"journal-article","created":{"date-parts":[[2014,10,10]],"date-time":"2014-10-10T05:55:44Z","timestamp":1412920544000},"page":"1128-1134","source":"Crossref","is-referenced-by-count":170,"title":["Cardiovascular outcomes and systemic anti\u2010inflammatory drugs in patients with severe psoriasis: 5\u2010year follow\u2010up of a Danish nationwide cohort"],"prefix":"10.1111","volume":"29","author":[{"given":"O.","family":"Ahlehoff","sequence":"first","affiliation":[{"name":"Department of Cardiology Roskilde Hospital University of Copenhagen Roskilde 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