{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T07:59:16Z","timestamp":1704441556253},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T00:00:00Z","timestamp":1413158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>scopy (Spectrophotometric Intracutaneous Analysis) enables non\u2010invasive analysis of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We wanted to determine whether <jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>scopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Volunteers and patients were measured by <jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>scopy at six spots on sun\u2010exposed and two spots on sun\u2010protected skin. Measurements were transformed by <jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>metrics into arbitrary units and statistically analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Melanin was shown to be higher with age (+1.73759\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), sun exposure (+47.03998 a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001), immunosuppression (+10.48526\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and lower in males (\u221226.50952 a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Collagen was lower with increasing age (\u22120.29162 a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and sun exposure (\u22126.85586\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) but higher with male sex (+8.34251\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and immunosuppression (+5.79171\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001). Haemoglobin was lower with increasing age (\u22120.23833\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0005), but higher with male sex (+18.51976\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001) and sun exposure (+13.74523\u00a0a.u.; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Haemoglobin content was not associated to immunosuppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results encourage the use of <jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>scopy as a tool to better gauge an individual patient's <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> risk factors. Further studies should help to better delineate <jats:styled-content style=\"fixed-case\">SIA<\/jats:styled-content>scopy as a prognostic tool.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12771","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T05:08:27Z","timestamp":1413176907000},"page":"1141-1147","source":"Crossref","is-referenced-by-count":2,"title":["Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised patients"],"prefix":"10.1111","volume":"29","author":[{"given":"D.W.","family":"Stimpfle","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Zurich Zurich Switzerland"},{"name":"Division of Nephrology University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Serra","sequence":"additional","affiliation":[{"name":"Division of Nephrology University Hospital Zurich Zurich 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