{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T14:53:31Z","timestamp":1770735211064,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T00:00:00Z","timestamp":1416268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The pathogenesis of chronic hand eczema (<jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content>) is multifactorial. Certain life\u2010style factors have been suggested as potential triggers of the disease, among them tobacco smoking. However, the few studies addressing the influence of smoking on <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> have been more or less limited to occupational hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to investigate the association of smoking status with clinical features like contact sensitization, irritant exposure, atopy and hyperhidrosis in a thoroughly characterized cohort of <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 153 patients with <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> underwent clinical examination and an interview about their history and course of disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly more smokers suffered from combined allergic and irritant hand eczema (25\/86) than non\u2010smokers (7\/67; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Nickel sensitization and palmar hyperhidrosis tended to be more frequent among smokers than among non\u2010smokers (nickel: 17\/86 smokers, 6\/67 non\u2010smokers; hyperhidrosis: 21\/84 smokers, 8\/64 non\u2010smokers). Among the smoking <jats:styled-content style=\"fixed-case\">CHE<\/jats:styled-content> patients with palmar hyperhidrosis, a significant proportion had contact allergies relevant contact allergies (16\/21, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results reveal a predominance of smokers among patients with combined allergic and irritant hand eczema as well as with hyperhidrosis and relevant contact sensitizations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12846","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T11:46:44Z","timestamp":1416311204000},"page":"2483-2486","source":"Crossref","is-referenced-by-count":32,"title":["Smoking is associated with combined allergic and irritant hand eczema, contact allergies and hyperhidrosis"],"prefix":"10.1111","volume":"29","author":[{"given":"S.","family":"Molin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Ruzicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Herzinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig Maximilian University Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700781"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1104084"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01362.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10526.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10394.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329433"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08930.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09991.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510036658"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09378.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13169"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5414\/DBX0183"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.04001.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0379.2009.07061.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233709103209"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.08.020"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05205.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0772"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.1394"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04640.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12846","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T08:05:37Z","timestamp":1695542737000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,18]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/jdv.12846"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12846","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,18]]}}}