{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:02:26Z","timestamp":1792544546959,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Verneuil's disease is a chronic inflammatory skin disease of the follicles in apocrine glands rich area of the skin (axillary, inguinal, anogenital) and is associated with a deficient skin innate immunity. It is characterized by the occurrence of nodules, abscesses, fistulas, scars. Recently, vitamin D has been shown to stimulate skin innate immunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The primary objective of the study was to assess whether Verneuil's disease was associated with vitamin D deficiency. The secondary objective was to determine whether vitamin D supplementation could improve inflammatory lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>First, 25(OH) vitamin D<jats:sub>3<\/jats:sub> serum levels in patients with Verneuil's disease followed at Nantes University Hospital were compared to those of healthy donors from the French Blood Bank. Then, a pilot study was conducted in 14 patients supplemented with vitamin D according to their vitamin D level at baseline at months 3 and 6. The endpoints at 6\u00a0months were decreased by at least 20% in the number of nodules and in the frequency of flare\u2010ups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010two patients (100%) had vitamin D deficiency (level &lt;30\u00a0ng\/mL) of whom 36% were severely deficient (level &lt;10\u00a0ng\/mL), having correlation with the disease severity (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03268) vs. 20 controls with vitamin D deficiency (91%) of whom 14% were severely deficient. In 14 patients, the supplementation significantly decreased the number of nodules at 6\u00a0months (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01133), and the endpoints were achieved in 79% of these patients. A correlation between the therapeutic success and the importance of the increase in vitamin D level after supplementation was observed (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01099).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that Verneuil's disease is associated with a major vitamin D deficiency, correlated with the disease severity. It suggests that vitamin D could significantly improve the inflammatory nodules, probably by stimulating the skin innate immunity. A larger randomized study is needed to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12857","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T07:10:42Z","timestamp":1418713842000},"page":"1347-1353","source":"Crossref","is-referenced-by-count":60,"title":["Verneuil's disease, innate immunity and vitamin D: a pilot study"],"prefix":"10.1111","volume":"29","author":[{"given":"A.","family":"Guillet","sequence":"first","affiliation":[{"name":"Service de Dermato\u2010Canc\u00e9rologie CHU H\u00f4tel\u2010Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Brocard","sequence":"additional","affiliation":[{"name":"Service de Dermato\u2010Canc\u00e9rologie CHU H\u00f4tel\u2010Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bach Ngohou","sequence":"additional","affiliation":[{"name":"Laboratoire de radio\u2010immunologie CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Graveline","sequence":"additional","affiliation":[{"name":"Laboratoire de radio\u2010immunologie CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010G.","family":"Leloup","sequence":"additional","affiliation":[{"name":"Laboratoire de radio\u2010immunologie CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ali","sequence":"additional","affiliation":[{"name":"Laboratoire de radio\u2010immunologie CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010M.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Service de sant\u00e9 publique PIMESP H\u00f4pital Saint Jacques Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Loirat","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang CHU H\u00f4tel Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Khammari","sequence":"additional","affiliation":[{"name":"Service de Dermato\u2010Canc\u00e9rologie CHU H\u00f4tel\u2010Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Dreno","sequence":"additional","affiliation":[{"name":"Service de Dermato\u2010Canc\u00e9rologie CHU H\u00f4tel\u2010Dieu Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10643.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.23"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.372"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.674193"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04123.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.315"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.033"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.07.020"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.14616"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.020"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.03.014"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03356.x"},{"key":"e_1_2_6_15_1","first-page":"50","article-title":"Approaches to measurement of vitamin D concentrations \u2010 immunoassays","volume":"243","author":"Ofenloch\u2010Haehnle B","year":"2012","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2013.06.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181ceb80c"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800751011"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-176"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550152384209"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.4.393"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10254.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10747.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903907"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq155"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425995"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.03.030"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12857","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:34:21Z","timestamp":1695558861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jdv.12857"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12857","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}