{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:47:02Z","timestamp":1784072822518,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["R-1100401"],"award-info":[{"award-number":["R-1100401"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["R-11004-02"],"award-info":[{"award-number":["R-11004-02"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V102C-047"],"award-info":[{"award-number":["V102C-047"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The previous literature has demonstrated the association of autoimmune and atopic diseases with vitiligo, but there has been no large\u2010scale nationwide study conducted to confirm this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study was conducted to clarify the comorbid profiles in vitiligo patients and thereby better understand their clinical scenarios and underlying pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective population\u2010based study conducted from 1996 to 2011 via the National Health Insurance Research Database in Taiwan. The differences in the prevalence of multiple autoimmune and atopic diseases between case subjects and controls were analysed by multiple logistic regression method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14883 vitiligo patients and 59532 controls were enroled. The prevalence of vitiligo was 0.064% and the peak of onset age was 40\u201359\u00a0years old. The non\u2010stratified analysis evidenced a significant association between vitiligo and several comorbid diseases, including alopecia areata, Hashimoto thyroiditis, myasthenia gravis, psoriasis, Graves' disease, Sj\u00f6gren's syndrome, systemic lupus erythematosus and atopic dermatitis. Vitiligo patients also had higher prevalence of multiple comorbidities than controls. In the age\u2010 and gender\u2010stratified analysis, increased risks of systemic lupus erythematosus and Sj\u00f6gren's syndrome were observed only in subjects aged 60\u201379. The association of vitiligo with myasthenia gravis and rheumatoid arthritis was identified only in the subgroup aged 20\u201339 and in females aged 60\u201379 respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study not only confirmed the significant association of vitiligo with multiple autoimmune and atopic diseases in Taiwan but also disclosed several unique findings, including the much lower prevalence of vitiligo, delayed onset of vitiligo by three decades, different associated comorbidity profiles comparing to westerners and the age\u2010 and gender\u2010specific approach for the vitiligo\u2010associated comorbidities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12870","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T07:32:11Z","timestamp":1418715131000},"page":"1362-1369","source":"Crossref","is-referenced-by-count":89,"title":["Comorbidity profiles in association with vitiligo: a nationwide population\u2010based study in Taiwan"],"prefix":"10.1111","volume":"29","author":[{"given":"Y.T.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Dermatology Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.Y.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Dermatology Wan Fang Hospital Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Public Health National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.Y.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.D.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.T.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.N.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Dermatology National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Dermatology National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.6.1203"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00023.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00244.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2000.00880.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370020107"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640010049006"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1985.tb05768.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90112-7"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08881.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2009.093278"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2007.00384.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.320"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00945.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00242.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247164"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347541201600408"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2013.570.574"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11198.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.1.7306"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.032"},{"key":"e_1_2_5_24_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1684\/ejd.2012.1656","article-title":"Seven cases of vitiligo complicated by atopic dermatitis: suggestive new spectrum of autoimmune vitiligo","volume":"22","author":"Tanemura A","year":"2012","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_25_1","first-page":"200","article-title":"Vitiligo and autoantibodies of celiac disease","volume":"4","author":"Shahmoradi Z","year":"2013","journal-title":"Int J Prev Med"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09274.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.0695"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0642"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2987"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0729"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.060"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2011.07.001"},{"key":"e_1_2_5_33_1","unstructured":"Institute N.H.R.National Health Research Database. Data subsets. Available at:http:\/\/nhird.nhri.org.tw\/en\/Data_Subsets.html(last accessed: 30 September 2013)."},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02848.x"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-6646(08)60004-2"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03696.x"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01813.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archinte.1996.00040041097008","article-title":"Prevalence of undiagnosed pernicious anemia in the elderly","volume":"156","author":"Ralph C","year":"1996","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-013-0352-1"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000224710.47263.70"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.2.200"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12870","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:34:50Z","timestamp":1695558890000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,16]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/jdv.12870"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12870","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,16]]}}}