{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:45:24Z","timestamp":1787798724429,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T00:00:00Z","timestamp":1416528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Benign familial chronic pemphigus, or Hailey\u2013Hailey disease (\n                    <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>\n                    ), is a recurrent bullous dermatitis that tends to have a chronic course with frequent relapses. Long\u2010term treatment options include surgery with skin grafting or dermabrasion. Both are highly invasive and carry significant risks and complications. More recently, \u2018laser\u2010abrasion\u2019 has been described as a less invasive option with a better side\u2010effect profile. In this article, we systematically review the safety and efficacy of carbon dioxide laser therapy as a long\u2010term treatment option for\n                    <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>\n                    , as well as provide a review of other lasers that have been reported with this goal. A total of 23 patients who had been treated with a carbon dioxide laser were identified. After treatment, 10 patients (43%) had had no recurrence, 10 (43%) had greater than 50% improvement, 2 (8%) had less than 50% improvement and 1 (4%) patient had no improvement at all (follow\u2010up period ranged from 4 to 144\u00a0months). Laser parameter variability was wide and adverse effects were minimal, including dyspigmentation and scarring. Reviewed evidence indicates this therapy offers a safe, effective treatment alternative for\n                    <jats:styled-content style=\"fixed-case\">HHD<\/jats:styled-content>\n                    with minimal risk of side\u2010effects. Larger, well\u2010designed studies are necessary to determine the optimal treatment parameters.\n                  <\/jats:p>","DOI":"10.1111\/jdv.12875","type":"journal-article","created":{"date-parts":[[2014,11,21]],"date-time":"2014-11-21T12:27:56Z","timestamp":1416572876000},"page":"1045-1052","source":"Crossref","is-referenced-by-count":21,"title":["Laser therapy for the treatment of Hailey\u2013Hailey disease: a systematic review with focus on carbon dioxide laser resurfacing"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5553-4507","authenticated-orcid":false,"given":"L.A.","family":"Falto\u2010Aizpurua","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.D.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Yazdani Abyaneh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nouri","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 33136 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2012.11.003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.4.423"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1992.01680150076009"},{"key":"e_1_2_7_5_1","first-page":"734","article-title":"Successful treatment of Hailey\u2010Hailey disease with acitretin","volume":"6","author":"Berger EM","year":"2007","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1996.tb01053.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2005.01948.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03360.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2012.1098"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.79857"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1297"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872011000500011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01290.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80201-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.66597"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962010000500021"},{"key":"e_1_2_7_17_1","first-page":"532","article-title":"Botulinum toxin A for the treatment of familial benign pemphigus","volume":"103","author":"Lopez\u2010Ferrer A","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630801958220"},{"key":"e_1_2_7_19_1","first-page":"715","article-title":"PUVA therapy in chronic benign familial Hailey\u2010Hailey pemphigus","volume":"170","author":"Hums R","year":"1984","journal-title":"Dermatol Monatsschr"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124802"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764170160260762"},{"key":"e_1_2_7_22_1","first-page":"568","article-title":"Surgical treatment of Hailey\u2010Hailey disease or benign chronic familial pemphigus. 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