{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:13:59Z","timestamp":1771640039394,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T00:00:00Z","timestamp":1417478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"EADV grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proper diagnosis of skin diseases relies on dermatopathology, the most important diagnostic technique in dermatology. Unfortunately, there are few dermatopathology institutions in sub\u2010Saharan Africa, where little is known about the spectrum of histopathological features observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the spectrum of dermatopathological diagnoses made in a sub\u2010Saharan African reference centre of a large, mainly rural area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>To retrospectively evaluate all dermatopathological diagnoses made over a period of 5 years at the Regional Dermatology Training Centre (<jats:styled-content style=\"fixed-case\">RDTC<\/jats:styled-content>) in Moshi, Tanzania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were a total of 1554 skin biopsy specimens. In 45% of cases, there were inflammatory diseases, most frequently lichenoid conditions. Cutaneous neoplasms represented 30.4% of all diagnoses, with Kaposi's sarcoma (<jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>) and, less frequently, squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) being the two most common neoplastic conditions. The latter also reflected the intensive management of persons with albinism in the <jats:styled-content style=\"fixed-case\">RDTC<\/jats:styled-content>. The distribution of histological diagnoses seemed to correlate with the overall clinical spectrum of cutaneous diseases managed in the <jats:styled-content style=\"fixed-case\">RDTC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this African study inflammatory conditions are the main burden of skin diseases leading to a diagnostic biopsy. Our findings provide further evidence that <jats:styled-content style=\"fixed-case\">KS<\/jats:styled-content>, primarily related to the high prevalence of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection is an epidemiological problem. Both <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> and basal cell carcinoma represent another relatively common malignant cutaneous neoplasms, reflecting the presence of specific populations at risk. The challenging spectrum of histological diagnoses observed in this specific African setting with basic working conditions shows that development of laboratory services of good standards and specific training in dermatopathology are urgently needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12877","type":"journal-article","created":{"date-parts":[[2014,12,2]],"date-time":"2014-12-02T11:43:01Z","timestamp":1417520581000},"page":"1370-1375","source":"Crossref","is-referenced-by-count":6,"title":["Dermatopathology in sub\u2010Saharan Africa: a systematic 5\u2010year analysis of all histopathological diagnoses from the Regional Dermatology Training Centre (<scp>RDTC<\/scp>) in Moshi, Tanzania"],"prefix":"10.1111","volume":"29","author":[{"given":"H.","family":"Beltraminelli","sequence":"first","affiliation":[{"name":"University Clinic for Dermatology Inselspital \u2013 Bern University Hospital Bern Switzerland"},{"name":"Regional Dermatology Training Centre at Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kiprono","sequence":"additional","affiliation":[{"name":"Regional Dermatology Training Centre at Kilimanjaro Christian Medical University College Moshi Tanzania"},{"name":"Department of Dermatology Provincial General Hospital Kakamega Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zuriel","sequence":"additional","affiliation":[{"name":"Pathology Department University of Nairobi Nairobi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Swai","sequence":"additional","affiliation":[{"name":"Pathology Department at the Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Giabbani","sequence":"additional","affiliation":[{"name":"University Clinic for Dermatology Inselspital \u2013 Bern University Hospital Bern Switzerland"},{"name":"Regional Dermatology Training Centre at Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Grossmann","sequence":"additional","affiliation":[{"name":"Regional Dermatology Training Centre at Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Masenga","sequence":"additional","affiliation":[{"name":"Regional Dermatology Training Centre at Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-12-7"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-10-765"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1996.tb03687.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0041-RA"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04953.x"},{"key":"e_1_2_8_7_1","first-page":"75","article-title":"Non\u2010tumor dermatoses diagnosed in the pathologic anatomy laboratory of the Tokoin University hospital center, Lom\u00e9 (Togo)","volume":"7","author":"Napo\u2010Koura G","year":"1997","journal-title":"Sante"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph2007040002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04790.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb04930.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.04954.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04920.x"},{"key":"e_1_2_8_13_1","unstructured":"BeltraminelliH.Focus on dermatopathology in developing countries. 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