{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:12:40Z","timestamp":1761718360423},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T00:00:00Z","timestamp":1418169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010melanoma skin cancer (NMSC) and melanoma are common malignancies in the US and may be associated with other types of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to determine whether NMSC and melanoma are associated with extra\u2010cutaneous cancers and identify modifiable risk factors for such an association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analysed data from 447\u00a0801 adult participants in the 1997\u20132011 National Health Interview Surveys. Survey logistic regression models were constructed that accounted for the complex sample weights. History of NMSC, melanoma and 27 primary extra\u2010cutaneous cancers was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NMSC was associated with increased odds of one (multinomial survey logistic regression, unadjusted odds ratio [95% CI]: 2.43 [2.20\u20132.68]) or multiple (2.94 [2.21\u20133.92]) extra\u2010cutaneous malignancies. Melanoma was also associated with increased odds of one (3.25 [2.70\u20133.90]) or multiple (6.11 [4.34\u20138.61]) extra\u2010cutaneous malignancies. Extra\u2010cutaneous cancers were more common in younger patients (ages 18\u201339 and 40\u201349\u00a0years) and Caucasians with NMSC or melanoma (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). Smokers with a history of NMSC or melanoma had even higher odds of extra\u2010cutaneous malignancy at ages 18\u201339 and 40\u201349\u00a0years compared to smokers without NMSC or melanoma (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). History of NMSC was associated with higher odds of malignancies of the bladder, brain, breast, colon, oesophagus, kidney, lung, lymphoma, melanoma, prostate, soft tissue, throat\/pharynx, thyroid and uterus. Melanoma was associated with malignancies of the bladder, breast, colon, kidney, lung, pancreas, prostate, soft tissue, throat\/pharynx, thyroid and uterus. The prevalence of extra\u2010cutaneous cancers increased between 1997 and 2011 in all subjects (4.51% and 5.73%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), with even higher rates of increase in those with history of NMSC or melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with history of NMSC and melanoma have increased odds of developing extra\u2010cutaneous cancers, especially those with younger age and smoking history.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12883","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T11:40:10Z","timestamp":1418211610000},"page":"1389-1397","source":"Crossref","is-referenced-by-count":14,"title":["Associations of non\u2010melanoma skin cancer and melanoma, extra\u2010cutaneous cancers and smoking in adults: a <scp>US<\/scp> population\u2010based study"],"prefix":"10.1111","volume":"29","author":[{"given":"J.I.","family":"Silverberg","sequence":"first","affiliation":[{"name":"Departments of Dermatology Preventive Medicine and Medical Social Sciences Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ratner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mount Sinai Beth Israel Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1540","article-title":"Risk of basal cell carcinoma in relation to alcohol intake and smoking","volume":"12","author":"Freedman DM","year":"2003","journal-title":"Cancer Epidemiol Biomarkers 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