{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:28:59Z","timestamp":1790357339892,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T00:00:00Z","timestamp":1421280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009906","name":"Grosserer A.V. Lykfeldt og hustrus Legat","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009906","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensen Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus University Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"crossref","award":["R73-A4284-13-S17"],"award-info":[{"award-number":["R73-A4284-13-S17"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Several antihypertensive drugs are photosensitizing and may therefore act as cocarcinogens with ultraviolet radiation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To examine whether antihypertensive drug use is associated with squamous cell carcinoma (\n SCC<\/jats:styled-content>\n ), basal cell carcinoma (\n BCC<\/jats:styled-content>\n ), and malignant melanoma (\n MM<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We used population\u2010based databases to conduct a case\u2013control study including all first\u2010time cases of\n SCC<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 2282),\n BCC<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 17\u00a0242), and\n MM<\/jats:styled-content>\n (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 3660) in northern Denmark, 1991\u20132010. We matched approximately 10 controls (\n n\u00a0<\/jats:italic>\n =\n \u00a0<\/jats:italic>\n 231\u00a0743) to each case by age, sex and county using risk\u2010set sampling. We used conditional logistic regression to compute odds ratios (\n OR<\/jats:styled-content>\n s) for skin cancer with 95% confidence intervals comparing ever users of antihypertensives (>2 previous prescriptions) with non\u2010users (\u22642 previous prescriptions). We adjusted for comorbidity and comedications. We further analysed use by duration (short term: <5\u00a0years; long term: \u22655\u00a0years) and intensity (low intensity or high intensity: <50% or \u226550% prescription coverage during total duration of use, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ever users of diuretics were at increased risk of\n SCC<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 1.19; 1.06\u20131.33), driven by potassium\u2010sparing agents alone (\n OR<\/jats:styled-content>\n 1.40; 1.09\u20131.80) or with low\u2010ceiling diuretics (\n OR<\/jats:styled-content>\n 2.68; 2.24\u20133.21) and by long\u2010term use (\n OR<\/jats:styled-content>\n 1.41; 1.16\u20131.72 at low intensity;\n OR<\/jats:styled-content>\n 1.44; 0.98\u20132.14 at high intensity). Ever users of sulphonamides (\n OR<\/jats:styled-content>\n 1.49; 1.04\u20132.12) and non\u2010aldosterone antagonist potassium\u2010sparing agents (\n OR<\/jats:styled-content>\n 2.26; 0.85\u20136.01) were at increased\n MM<\/jats:styled-content>\n risk. The latter was also associated with\n BCC<\/jats:styled-content>\n (\n OR<\/jats:styled-content>\n 1.47; 1.00\u20132.17), as was low\u2010ceiling diuretics combined with potassium\u2010sparing agents (\n OR<\/jats:styled-content>\n 1.23; 1.12\u20131.35). Long\u2010term, low\u2010intensity (\n OR<\/jats:styled-content>\n 1.53; 1.05\u20132.23) and high\u2010intensity (\n OR<\/jats:styled-content>\n 1.44; 0.56\u20133.69) angiotensin receptor blocker use was associated with\n MM<\/jats:styled-content>\n . Estimates for angiotensin\u2010converting enzyme inhibitors, \u03b2\u2010blockers, and calcium channel blockers were inconsistent or weak (<20% increased).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Long\u2010term angiotensin receptor blocker use was associated with risk of\n MM<\/jats:styled-content>\n . Moreover, long\u2010term diuretic use was associated with\n SCC<\/jats:styled-content>\n risk, driven by potassium\u2010sparing agents alone or in combination with low\u2010ceiling diuretics.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.12921","type":"journal-article","created":{"date-parts":[[2015,1,15]],"date-time":"2015-01-15T09:45:30Z","timestamp":1421315130000},"page":"1545-1554","source":"Crossref","is-referenced-by-count":95,"title":["Use of antihypertensive drugs and risk of skin cancer"],"prefix":"10.1111","volume":"29","author":[{"given":"S.A.J.","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Division of Biostatistics College of Public Health Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Division of Biostatistics College of Public Health Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mehnert","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Lemeshow","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"},{"name":"Division of Biostatistics College of Public Health Ohio State University Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.T.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61196-X"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70937-5"},{"key":"e_1_2_5_4_1","unstructured":"American Cancer Society.Cancer Facts & Figures 2012. 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