{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:15:08Z","timestamp":1783116908810,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T00:00:00Z","timestamp":1419811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007688","name":"American University of Beirut","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007688","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Type I interferon (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>) signature has been implicated in alopecia areata (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>). However, type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content> source has never been documented. Plasmacytoid dendritic cells (<jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>s) are generally known to be the main source and most potent producers of local type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s. Their role in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> pathogenesis has never been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Investigate <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> role in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nineteen <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> cases were retrieved from our database and were immunohistochemically tested for <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> occurrence and activity using anti\u2010<jats:styled-content style=\"fixed-case\">BDCA<\/jats:styled-content>\u20102 and anti\u2010MxA antibodies respectively. Comparison to 10 trichotillomania and 7 androgenetic alopecia (<jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>) cases was also done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasmacytoid dendritic cells were present in all <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> cases in a peri\u2010bulbar location and, as indirectly assessed by MxA expression, were in an active state producing type I <jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>s. All trichotillomania cases showed the presence of <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content>s, though significantly less abundant and in a different distribution (mainly superficial perivascular) than that in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> presence and MxA expression were absent in <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Plasmacytoid dendritic cells constitute a central component of the peribulbar infiltrate in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> suggesting a significant role in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> pathogenesis. Additionally, <jats:styled-content style=\"fixed-case\">PDC<\/jats:styled-content> distribution could help in microscopically differentiating <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> from trichotillomania or <jats:styled-content style=\"fixed-case\">AGA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12932","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T14:21:08Z","timestamp":1419862868000},"page":"119-123","source":"Crossref","is-referenced-by-count":66,"title":["Plasmacytoid dendritic cells in alopecia areata: missing link?"],"prefix":"10.1111","volume":"30","author":[{"given":"J.","family":"Abou Rahal","sequence":"first","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kurban","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010G.","family":"Kibbi","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Abbas","sequence":"additional","affiliation":[{"name":"Dermatology Department American University of Beirut Medical Center Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2009.03439.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09775.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.0816"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.194.12.1823"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.256"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/43.1.7822763"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000065841"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079904"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03327.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji207"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2008.07095"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1001\/archderm.1992.01680130082010","article-title":"Incidence of alopecia areata in lupus erythematosus","volume":"128","author":"Werth VP","year":"1992","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00875.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.08.032"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.04.039"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09114"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408506102"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.4.2396"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101102"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.12932","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.12932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:18:18Z","timestamp":1695550698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.12932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/jdv.12932"],"URL":"https:\/\/doi.org\/10.1111\/jdv.12932","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,29]]}}}