{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:11:11Z","timestamp":1777461071337,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NUCATS","award":["8UL1TR000150"],"award-info":[{"award-number":["8UL1TR000150"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis has been linked to increased malignancy risk, particularly lympho\u2010haematopoietic and non\u2010melanoma skin cancers; however, its association with cutaneous melanoma remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine if there is an association between melanoma and psoriasis in a large, urban academic population through an electronic medical record database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched our institution's electronic medical record database (<jats:styled-content style=\"fixed-case\">EDW<\/jats:styled-content>\u2010Electronic Data Warehouse) from 1\/2001 to 11\/2013. Subjects were identified by <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\u20109 codes. Melanoma diagnosis was included only if documented at least 1\u00a0month after the psoriasis diagnosis was documented. Odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) was obtained for association between cutaneous melanoma and psoriasis. The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> was then adjusted for phototherapy and age. To minimize detection bias, we also obtained the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for association between cutaneous melanoma and atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 10\u00a0947 patients with psoriasis, 64 of whom had a subsequent diagnosis of cutaneous melanoma. We detected a significant association between melanoma and psoriasis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.77; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.38\u20132.26; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001; total <jats:italic>n<\/jats:italic>\u00a0=\u00a01\u00a0525\u00a0252). After adjusting for phototherapy and age, a statistically significant association between melanoma and psoriasis remained detectable (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.9; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.55\u20132.55; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.64; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.17\u20132.26; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003 respectively). The <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for melanoma with atopic dermatitis in the same patient database showed a statistically significant inverse association between the two diseases (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.35; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.16\u20130.73; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings show a statistically significant association between psoriasis and melanoma. After adjusting the <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> for phototherapy and age, a statistically significant association remained. Further investigations exploring these associations are warranted in order to establish the relative risk for melanoma in psoriasis patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12949","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T03:23:51Z","timestamp":1422415431000},"page":"83-85","source":"Crossref","is-referenced-by-count":12,"title":["Co\u2010existence of psoriasis and melanoma in a large urban academic centre population: a cross\u2010sectional retrospective study"],"prefix":"10.1111","volume":"30","author":[{"given":"T.","family":"Bhattacharya","sequence":"first","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rademaker","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Chicago IL USA"},{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"},{"name":"Robert H. Lurie Comprehensive Cancer Center Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.M.","family":"Al\u2010Mudaimeagh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kiguradze","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Northwestern University Clinical and Translational Sciences (NUCATS) Institute Northwestern University Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.P.","family":"West","sequence":"additional","affiliation":[{"name":"Department of Dermatology Northwestern University Chicago IL USA"},{"name":"Robert H. 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