{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:32:47Z","timestamp":1751376767177},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal management of <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ycobacterium chelonae<\/jats:italic> disease in immunocompromised patients remains unclear. A combination of antimicrobial agents is recommended as monotherapy with clarithromycin has been associated with clinical failures due to acquired resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to report the efficacy and tolerability of linezolid in association with clarithromycin for the treatment of <jats:italic>M.\u00a0chelonae<\/jats:italic> infections in immunocompromised patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe four immunocompromised patients treated by linezolid and clarithromycin for cutaneous <jats:italic>M.\u00a0chelonae<\/jats:italic> disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This combination was associated with rapid clinical efficacy in all patients with no relapse observed after a median follow\u2010up of 2.25\u00a0years (1.4\u00a0years). However, this treatment was responsible for frequent adverse events including thrombocytopaenia, myalgia and mitochondrial toxicity. All adverse effects were reversible after linezolid discontinuation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We therefore suggest linezolid\/clarithromycin combination as the initial therapeutic strategy for <jats:italic>M.\u00a0chelonae<\/jats:italic> skin infections in immunocompromised patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.12965","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T05:57:28Z","timestamp":1423807048000},"page":"101-105","source":"Crossref","is-referenced-by-count":7,"title":["Induction therapy with linezolid\/clarithromycin combination for <i><scp>M<\/scp>ycobacterium chelonae<\/i> skin infections in immunocompromised hosts"],"prefix":"10.1111","volume":"30","author":[{"given":"P.","family":"Parize","sequence":"first","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker\u2010Pasteur, IHU Imagine, H\u00f4pital Necker\u2010Enfants 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