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A mean disease incidence of 6.0 per 100\u00a0000 person\u2010years and an average prevalence of 1% has been reported in Europe.\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    has the highest impact on patients' quality of life among all assessed dermatological diseases.\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is associated with a variety of concomitant and secondary diseases, such as obesity, metabolic syndrome, inflammatory bowel disease, e.g. Crohn's disease, spondyloarthropathy, follicular occlusion syndrome and other hyperergic diseases. The central pathogenic event in\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is believed to be the occlusion of the upper part of the hair follicle leading to a perifollicular lympho\u2010histiocytic inflammation. A highly significant association between the prevalence of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    and current smoking (Odds ratio 12.55) and overweight (Odds ratio 1.1 for each body mass index unit) has been documented. The European S1\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    guideline suggests that the disease should be treated based on its individual subjective impact and objective severity. Locally recurring lesions can be treated by classical surgery or\n                    <jats:styled-content style=\"fixed-case\">LASER<\/jats:styled-content>\n                    techniques, whereas medical treatment either as monotherapy or in combination with radical surgery is more appropriate for widely spread lesions. Medical therapy may include antibiotics (clindamycin plus rifampicine, tetracyclines), acitretin and biologics (adalimumab, infliximab). A Hurley severity grade\u2010relevant treatment of\n                    <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                    is recommended by the expert group following a treatment algorithm. Adjuvant measurements, such as pain management, treatment of superinfections, weight loss and tobacco abstinence have to be considered.\n                  <\/jats:p>","DOI":"10.1111\/jdv.12966","type":"journal-article","created":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T04:29:06Z","timestamp":1422592146000},"page":"619-644","source":"Crossref","is-referenced-by-count":957,"title":["European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa"],"prefix":"10.1111","volume":"29","author":[{"given":"C.C.","family":"Zouboulis","sequence":"first","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Desai","sequence":"additional","affiliation":[{"name":"St Johns Institute of Dermatology Guys &amp; St Thomas' NHS Trust London 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